MIRACUM: Medical Informatics in Research and Care in University Medicine

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Prokosch HU, Acker T, Bernarding J, Binder H, Boeker M, Boerries M, Daumke P, Ganslandt T, Hesser J, Hoening G, Neumaier M, Marquardt K, Renz H, Rothkoetter HJ, Schade-Brittinger C, Schmuecker P, Schüttler J, Sedlmayr M, Serve H, Sohrabi K, Storf H
Zeitschrift: Methods of Information in Medicine
Jahr der Veröffentlichung: 2018
Band: 57
Heftnummer: S 01
Seitenbereich: e82-e91
ISSN: 0026-1270
eISSN: 2511-705X


Abstract

INTRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on the German Medical Informatics Initiative. Similar to other large international data sharing networks (e.g. OHDSI, PCORnet, eMerge, RD-Connect) MIRACUM is a consortium of academic and hospital partners as well as one industrial partner in eight German cities which have joined forces to create interoperable data integration centres (DIC) and make data within those DIC available for innovative new IT solutions in patient care and medical research.
OBJECTIVES: Sharing data shall be supported by common interoperable tools and services, in order to leverage the power of such data for biomedical discovery and moving towards a learning health system. This paper aims at illustrating the major building blocks and concepts which MIRACUM will apply to achieve this goal.
GOVERNANCE AND POLICIES: Besides establishing an efficient governance structure within the MIRACUM consortium (based on the steering board, a central administrative office, the general MIRACUM assembly, six working groups and the international scientific advisory board), defining DIC governance rules and data sharing policies, as well as establishing (at each MIRACUM DIC site, but also for MIRACUM in total) use and access committees are major building blocks for the success of such an endeavor.
ARCHITECTURAL FRAMEWORK AND METHODOLOGY: The MIRACUM DIC architecture builds on a comprehensive ecosystem of reusable open source tools (MIRACOLIX), which are linkable and interoperable amongst each other, but also with the existing software environment of the MIRACUM hospitals. Efficient data protection measures, considering patient consent, data harmonization and a MIRACUM metadata repository as well as a common data model are major pillars of this framework. The methodological approach for shared data usage relies on a federated querying and analysis concept.
USE CASES: MIRACUM aims at proving the value of their DIC with three use cases: IT support for patient recruitment into clinical trials, the development and routine care implementation of a clinico-molecular predictive knowledge tool, and molecular-guided therapy recommendations in molecular tumor boards.
RESULTS: Based on the MIRACUM DIC release in the nine months conceptual phase first large scale analysis for stroke and colorectal cancer cohorts have been pursued.
DISCUSSION: Beyond all technological challenges successfully applying the MIRACUM tools for the enrichment of our knowledge about diagnostic and therapeutic concepts, thus supporting the concept of a Learning Health System will be crucial for the acceptance and sustainability in the medical community and the MIRACUM university hospitals.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Prokosch, Hans-Ulrich Prof. Dr.
Lehrstuhl für Medizinische Informatik
Schüttler, Jürgen Prof. Dr.
Lehrstuhl für Anästhesiologie
Sedlmayr, Martin Dr.
Lehrstuhl für Medizinische Informatik


Einrichtungen weiterer Autorinnen und Autoren

Albert-Ludwigs-Universität Freiburg
Averbis GmbH
Goethe-Universität Frankfurt am Main
Hochschule Mannheim University of Applied Sciences
Johannes Gutenberg-Universität Mainz
Justus-Liebig-Universität Gießen
Otto-von-Guericke-Universität Magdeburg
Philipps-Universität Marburg
Ruprecht-Karls-Universität Heidelberg
Technische Hochschule Mittelhessen - University of Applied Sciences
Universitätsklinikum Gießen und Marburg (UKGM)


Zitierweisen

APA:
Prokosch, H.-U., Acker, T., Bernarding, J., Binder, H., Boeker, M., Boerries, M.,... Storf, H. (2018). MIRACUM: Medical Informatics in Research and Care in University Medicine. Methods of Information in Medicine, 57(S 01), e82-e91. https://dx.doi.org/10.3414/ME17-02-0025

MLA:
Prokosch, Hans-Ulrich, et al. "MIRACUM: Medical Informatics in Research and Care in University Medicine." Methods of Information in Medicine 57.S 01 (2018): e82-e91.

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Zuletzt aktualisiert 2019-30-07 um 09:18