Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Nersesyan Y, Demirkhanyan L, Cabezas-Bratesco D, Oakes V, Kusuda R, Dawson T, Sun X, Cao C, Cohen AM, Chelluboina B, Veeravalli KK, Zimmermann K, Domene C, Brauchi S, Zakharian E
Zeitschrift: Cell Reports
Jahr der Veröffentlichung: 2017
Band: 21
Heftnummer: 6
Seitenbereich: 1681-1691
ISSN: 2211-1247


Abstract

Oxytocin is a hormone with various actions. Oxytocin-containing parvocellular neurons project to the brainstem and spinal cord. Oxytocin release from these neurons suppresses nociception of inflammatory pain, the molecular mechanism of which remains unclear. Here, we report that the noxious stimulus receptor TRPV1 is an ionotropic oxytocin receptor. Oxytocin elicits TRPV1 activity in native and heterologous expression systems, regardless of the presence of the classical oxytocin receptor. In TRPV1 knockout mice, DRG neurons exhibit reduced oxytocin sensitivity relative to controls, and oxytocin injections significantly attenuate capsaicin-induced nociception in in vivo experiments. Furthermore, oxytocin potentiates TRPV1 in planar lipid bilayers, supporting a direct agonistic action. Molecular modeling and simulation experiments provide insight into oxytocin-TRPV1 interactions, which resemble DkTx. Together, our findings suggest the existence of endogenous regulatory pathways that modulate nociception via direct action of oxytocin on TRPV1, implying its analgesic effect via channel desensitization.


FAU-Autoren / FAU-Herausgeber

Zimmermann, Katharina Prof. Dr. med.
Heisenbergprofessur für Experimentelle Schmerzforschung


Autor(en) der externen Einrichtung(en)
Dalhousie University
Duke University
King’s College London
Universidad Austral de Chile
University of Illinois at Urbana-Champaign


Zitierweisen

APA:
Nersesyan, Y., Demirkhanyan, L., Cabezas-Bratesco, D., Oakes, V., Kusuda, R., Dawson, T.,... Zakharian, E. (2017). Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1. Cell Reports, 21(6), 1681-1691. https://dx.doi.org/10.1016/j.celrep.2017.10.063

MLA:
Nersesyan, Yelena, et al. "Oxytocin Modulates Nociception as an Agonist of Pain-Sensing TRPV1." Cell Reports 21.6 (2017): 1681-1691.

BibTeX: 

Zuletzt aktualisiert 2018-29-11 um 08:23