Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry

Worm M, Francuzik W, Renaudin JM, Bilo MB, Cardona V, Hofmeier KS, Kohli A, Bauer A, Christoff G, Cichocka-Jarosz E, Hawranek T, Hourihane JO, Lange L, Mahler V, Muraro A, Papadopoulos NG, Pfoehler C, Poziomkowska-Gesicka I, Rueff F, Spindler T, Treudler R, Fernandez-Rivas M, Doelle S (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 73

Pages Range: 1322-1330

Journal Issue: 6

DOI: 10.1111/all.13380

Abstract

BACKGROUND: Preventive measures to decrease the frequency and intensity of anaphylactic events are essential to provide optimal care for allergic patients. Aggravating factors may trigger or increase the severity of anaphylaxis and therefore need to be recognized and avoided. OBJECTIVE: To identify and prioritize factors associated with an increased risk of developing severe anaphylaxis. METHODS: Data from the Anaphylaxis Registry (122 centers in 11 European countries) were used in logistic regression models considering existing severity grading systems, elicitors, and symptoms to identify the relative risk of factors on the severity of anaphylaxis. RESULTS: We identified higher age and concomitant mastocytosis (OR: 3.1, CI: 2.6-3.7) as the most important predictors for an increased risk of severe anaphylaxis. Vigorous physical exercise (OR: 1.5, CI: 1.3-1.7), male sex (OR: 1.2, CI: 1.1-1.3), and psychological burden (OR: 1.4, CI: 1.2-1.6) were more often associated with severe reactions. Additionally, intake of beta-blockers (OR: 1.9, CI: 1.5-2.2) and ACE-I (OR: 1.28, CI: 1.05, 1.51) in temporal proximity to allergen exposition was identified as an important factor in logistic regression analysis. CONCLUSION: Our data suggest it may be possible to identify patients who require intensified preventive measures due to their relatively higher risk for severe anaphylaxis by considering endogenous and exogenous factors.

Authors with CRIS profile

Additional Organisation(s)

Involved external institutions

Charité - Universitätsmedizin Berlin Germany (DE) Centre Hospitalier Universitaire de Nancy / CHU Hôpitaux de Brabois France (FR) Azienda Ospedaliero Universitaria Ospedali Riuniti Ancona Italy (IT) Vall d'Hebron University Hospital / Hospital Universitari Vall d'Hebron Spain (ES) Universitätsspital Basel Switzerland (CH) Universitäts-Kinderspital Zürich Switzerland (CH) Technische Universität Dresden Germany (DE) Medical University Sofia / Медицински университет Bulgaria (BG) Jagiellonian University / Uniwersytet Jagielloński (UJ) Poland (PL) Paracelsus Medizinische Privatuniversität Austria (AT) University College Cork (UCC) Ireland (IE) Klinikum St. Marien Amberg Germany (DE) University of Padua / Universita degli Studi di Padova Italy (IT) National and Kapodistrian University of Athens Greece (GR) Universitätsklinikum des Saarlandes (UKS) Germany (DE) Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU) Poland (PL) Klinikum der Universität München (Großhadern und Innenstadt) Germany (DE) Fachkliniken Wangen Germany (DE) Universität Leipzig Germany (DE) Hospital Clínico San Carlos Spain (ES)

How to cite

APA:

Worm, M., Francuzik, W., Renaudin, J.-M., Bilo, M.B., Cardona, V., Hofmeier, K.S.,... Doelle, S. (2018). Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry. Allergy, 73(6), 1322-1330. https://dx.doi.org/10.1111/all.13380

MLA:

Worm, M., et al. "Factors increasing the risk for a severe reaction in anaphylaxis: An analysis of data from The European Anaphylaxis Registry." Allergy 73.6 (2018): 1322-1330.

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