The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts

Journal article


Publication Details

Author(s): Recke A, Konitzer S, Lemcke S, Freitag M, Sommer NM, Abdelhady M, Amoli MM, Benoit S, El-Chennawy F, Eldarouti M, Eming R, Glaeser R, Guenther C, Hadaschik E, Homey B, Lieb W, Peitsch WK, Pfoehler C, Robati RM, Saeedi M, Sardy M, Sticherling M, Uzun S, Worm M, Zillikens D, Ibrahim S, Vidarsson G, Schmidt E
Journal: Frontiers in Immunology
Publication year: 2018
Volume: 9
ISSN: 1664-3224


Abstract

IgG3 is the IgG subclass with the strongest effector functions among all four IgG subclasses and the highest degree of allelic variability among all constant immunoglobulin genes. Due to its genetic position, IgG3 is often the first isotype an antibody switches to before IgG1 or IgG4. Compared with the other IgG subclasses, it has a reduced half-life which is probably connected to a decreased affinity to the neonatal Fc receptor (FcRn). However, a few allelic variants harbor an amino acid replacement of His435 to Arg that reverts the half-life of the resulting IgG3 to the same level as the other IgG subclasses. Because of its functional impact, we hypothesized that the p.Arg435His variation could be associated with susceptibility to autoantibody-mediated diseases like pemphigus vulgaris (PV) and bullous pemphigoid (BP). Using a set of samples from German, Turkish, Egyptian, and Iranian patients and controls, we were able to demonstrate a genetic association of the p.Arg435His variation with PV risk, but not with BP risk. Our results suggest a hitherto unknown role for the function of IgG3 in the pathogenesis of PV.


FAU Authors / FAU Editors

Sticherling, Michael Prof. Dr.
Professur für Dermatologie


External institutions with authors

Akdeniz University
Cairo University
Charité - Universitätsmedizin Berlin
Christian-Albrechts-Universität zu Kiel
Heinrich-Heine-Universität Düsseldorf
Ludwig-Maximilians-Universität (LMU)
Mansoura University / جامعة المنصورة
Philipps-Universität Marburg
Ruprecht-Karls-Universität Heidelberg
Sanquin
Shahid Beheshti University of Medical Sciences
Tehran University of Medical Sciences
Universität des Saarlandes (UdS)
Universitätsklinikum Carl Gustav Carus Dresden
Universitätsklinikum Würzburg
Universität zu Lübeck


How to cite

APA:
Recke, A., Konitzer, S., Lemcke, S., Freitag, M., Sommer, N.M., Abdelhady, M.,... Schmidt, E. (2018). The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts. Frontiers in Immunology, 9. https://dx.doi.org/10.3389/fimmu.2018.01788

MLA:
Recke, Andreas, et al. "The p.Arg435His Variation of IgG3 With High Affinity to FcRn Is Associated With Susceptibility for Pemphigus Vulgaris-Analysis of Four Different Ethnic Cohorts." Frontiers in Immunology 9 (2018).

BibTeX: 

Last updated on 2019-17-04 at 08:17