The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells

Journal article


Publication Details

Author(s): Lafita-Navarro MC, Kim M, Borenstein-Auerbach N, Venkateswaran N, Hao YH, Ray R, Brabletz T, Scaglioni PP, Shay JW, Conacci-Sorrell M
Journal: Genes & Development
Publication year: 2018
Volume: 32
Journal issue: 19-20
Pages range: 1303-1308
ISSN: 0890-9369
eISSN: 1549-5477


Abstract

MYC enhances protein synthesis by regulating genes involved in ribosome biogenesis and protein translation. Here, we show that MYC-induced protein translation is mediated by the transcription factor aryl hydrocarbon receptor (AHR), which is induced by MYC in colonic cells. AHR promotes protein synthesis by activating the transcription of genes required for ribosome biogenesis and protein translation, including OGFOD1 and NOLC1. Using surface sensing of translation (SUnSET) to measure global protein translation, we found that silencing AHR or its targets diminishes protein synthesis. Therefore, targeting AHR or its downstream pathways could provide a novel approach to limit biomass production in MYC-driven tumors.


FAU Authors / FAU Editors

Brabletz, Thomas Prof. Dr. med.
Lehrstuhl für Experimentelle Medizin mit dem Schwerpunkt Molekulare Pathogeneseforschung


External institutions with authors

University of Cincinnati
University of Texas Southwestern Medical Center (UT Southwestern)


How to cite

APA:
Lafita-Navarro, M.C., Kim, M., Borenstein-Auerbach, N., Venkateswaran, N., Hao, Y.-H., Ray, R.,... Conacci-Sorrell, M. (2018). The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells. Genes & Development, 32(19-20), 1303-1308. https://dx.doi.org/10.1101/gad.313007.118

MLA:
Lafita-Navarro, M. Carmen, et al. "The aryl hydrocarbon receptor regulates nucleolar activity and protein synthesis in MYC-expressing cells." Genes & Development 32.19-20 (2018): 1303-1308.

BibTeX: 

Last updated on 2019-17-09 at 09:32