The molecular fingerprint of lung inflammation after blunt chest trauma
Ehrnthaller C, Flierl M, Perl M, Denk S, Unnewehr H, Ward PA, Radermacher P, Ignatius A, Gebhard F, Chinnaiyan A, Huber-Lang M (2015)
Publication Status: Published
Publication Type: Journal article
Publication year: 2015
Journal
Publisher: BIOMED CENTRAL LTD
Book Volume: 20
DOI: 10.1186/s40001-015-0164-y
Abstract
Background: After severe blunt chest trauma, the development of an acute lung injury (ALI) is often associated with severe or even lethal complications. Especially in multiple injured patients after blunt chest trauma ALI/ARDS [acute respiratory distress syndrome (ARDS)] is frequent. However, in the initial posttraumatic phase, inflammatory clinical signs are often not apparent and underlying changes in gene-expression profile are unknown.Methods: Therefore, inflammation in lung tissue following blunt chest trauma was characterized in a well-defined bilateral lung injury model. Using DNA microarrays representing 9240 genes, the temporal sequence of blunt chest trauma-induced gene-expression patterns in lung tissue was examined.Results: The results suggest an activation of a highly complex transcriptional program in response to chest trauma. Chest trauma led to elevated expression levels of inflammatory and coagulatory proteins (such as TNF alpha receptor, IL-1 alpha, IL-1 beta, C3, NF-kappa B and plasminogen activator). However, upregulation of proteins was found, usually incoherent of exerting effects in blunt thoracic trauma (pendrin, resistin, metallothionein and glucocorticoid-induced leucine zipper). Furthermore, significant downregulation was observed as early as 10 min after trauma for cytokines and complement factors (LCR-1, C4) as well as for intracellular signaling molecules (inhibitory protein phosphatase) and ion-channels (voltage-dependent Ca2+ channel).Conclusions: Taken together, the provided global perspective of the inflammatory response following blunt chest trauma could provide a molecular framework for future research in trauma pathophysiology.
Authors with CRIS profile
Involved external institutions
Universität Ulm
Germany (DE)
University of Colorado System
United States (USA) (US)
University of Michigan
United States (USA) (US)
Berufsgenossenschaftliche Unfallklinik (BGU) Murnau
Germany (DE)
Germany (DE)
University of Colorado System
United States (USA) (US)
University of Michigan
United States (USA) (US)
Berufsgenossenschaftliche Unfallklinik (BGU) Murnau
Germany (DE)
How to cite
APA:
Ehrnthaller, C., Flierl, M., Perl, M., Denk, S., Unnewehr, H., Ward, P.A.,... Huber-Lang, M. (2015). The molecular fingerprint of lung inflammation after blunt chest trauma. European Journal of Medical Research, 20. https://doi.org/10.1186/s40001-015-0164-y
MLA:
Ehrnthaller, Christian, et al. "The molecular fingerprint of lung inflammation after blunt chest trauma." European Journal of Medical Research 20 (2015).
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