Nanoparticles for radiooncology: Mission, vision, challenges

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Kunz-Schughart LA, Dubrovska A, Peitzsch C, Ewe A, Aigner A, Schellenburg S, Muders MH, Hampel S, Cirillo G, Iemma F, Tietze R, Alexiou C, Stephan H, Zarschler K, Vittorio O, Kavallaris M, Parak WJ, Maedler L, Pokhrel S
Zeitschrift: Biomaterials
Jahr der Veröffentlichung: 2017
Band: 120
Seitenbereich: 155-184
ISSN: 0142-9612


Abstract

Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells. In order to progress the introduction of nanoparticles in radiooncology, due to the highly interdisciplinary nature, expertise in chemistry, radiobiology and translational research is needed. In this report recent insights and promising policies to design nanotechnology-based therapeutics for tumor radiosensitization will be discussed. An attempt is made to cover the entire field from preclinical development to clinical studies. Hence, this report illustrates (1) the radio- and tumor-biological rationales for combining nanostructures with radiotherapy, (2) tumor-site targeting strategies and mechanisms of cellular uptake, (3) biological response hypotheses for new nanomaterials of interest, and (4) challenges to translate the research findings into clinical trials.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Professur für Nanomedizin


Einrichtungen weiterer Autorinnen und Autoren

Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (IFW) / Leibniz Institute for Solid State and Materials Research Dresden
Philipps-Universität Marburg
Technische Universität Dresden
Università della Calabria (UNICAL)
Universität Bremen
Universität Leipzig
University of New South Wales (UNSW)


Zitierweisen

APA:
Kunz-Schughart, L.A., Dubrovska, A., Peitzsch, C., Ewe, A., Aigner, A., Schellenburg, S.,... Pokhrel, S. (2017). Nanoparticles for radiooncology: Mission, vision, challenges. Biomaterials, 120, 155-184. https://dx.doi.org/10.1016/j.biomaterials.2016.12.010

MLA:
Kunz-Schughart, Leoni A., et al. "Nanoparticles for radiooncology: Mission, vision, challenges." Biomaterials 120 (2017): 155-184.

BibTeX: 

Zuletzt aktualisiert 2018-09-11 um 12:08