Nanoparticles for radiooncology: Mission, vision, challenges

Kunz-Schughart LA, Dubrovska A, Peitzsch C, Ewe A, Aigner A, Schellenburg S, Muders MH, Hampel S, Cirillo G, Iemma F, Tietze R, Alexiou C, Stephan H, Zarschler K, Vittorio O, Kavallaris M, Parak WJ, Maedler L, Pokhrel S (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Biomaterials Elsevier

Book Volume: 120

Pages Range: 155-184

DOI: 10.1016/j.biomaterials.2016.12.010

Abstract

Cancer is one of the leading non-communicable diseases with highest mortality rates worldwide. About half of all cancer patients receive radiation treatment in the course of their disease. However, treatment outcome and curative potential of radiotherapy is often impeded by genetically and/or environmentally driven mechanisms of tumor radioresistance and normal tissue radiotoxicity. While nanomedicine-based tools for imaging, dosimetry and treatment are potential keys to the improvement of therapeutic efficacy and reducing side effects, radiotherapy is an established technique to eradicate the tumor cells. In order to progress the introduction of nanoparticles in radiooncology, due to the highly interdisciplinary nature, expertise in chemistry, radiobiology and translational research is needed. In this report recent insights and promising policies to design nanotechnology-based therapeutics for tumor radiosensitization will be discussed. An attempt is made to cover the entire field from preclinical development to clinical studies. Hence, this report illustrates (1) the radio- and tumor-biological rationales for combining nanostructures with radiotherapy, (2) tumor-site targeting strategies and mechanisms of cellular uptake, (3) biological response hypotheses for new nanomaterials of interest, and (4) challenges to translate the research findings into clinical trials.

Authors with CRIS profile

Christoph Alexiou Professur für Nanomedizin

Involved external institutions

Technische Universität Dresden DE Germany (DE) Universität Leipzig DE Germany (DE) Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden e.V. (IFW) / Leibniz Institute for Solid State and Materials Research Dresden DE Germany (DE) Università della Calabria (UNICAL) IT Italy (IT) Universität Bremen DE Germany (DE) Helmholtz-Zentrum Dresden-Rossendorf (HZDR) DE Germany (DE) University of New South Wales (UNSW) AU Australia (AU) Philipps-Universität Marburg DE Germany (DE)

How to cite

APA:

Kunz-Schughart, L.A., Dubrovska, A., Peitzsch, C., Ewe, A., Aigner, A., Schellenburg, S.,... Pokhrel, S. (2017). Nanoparticles for radiooncology: Mission, vision, challenges. Biomaterials, 120, 155-184. https://dx.doi.org/10.1016/j.biomaterials.2016.12.010

MLA:

Kunz-Schughart, Leoni A., et al. "Nanoparticles for radiooncology: Mission, vision, challenges." Biomaterials 120 (2017): 155-184.

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