Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers

Journal article


Publication Details

Author(s): Abe O, Ono T, Sato H, Mueller F, Ogata H, Miura I, Shikama Y, Yabe H, Onoue S, Fromm M, Kimura J, Misaka S
Journal: European Journal of Clinical Pharmacology
Publication year: 2018
Volume: 74
Journal issue: 6
Pages range: 775-783
ISSN: 0031-6970


Abstract

PURPOSE: The aim of the present study is to investigate a possible role of a single dose of (-)-epigallocatechin gallate (EGCG), the major catechin in green tea, for the pharmacokinetic interaction between green tea and nadolol in humans.
METHODS: In a randomized three-phase crossover study, 13 healthy volunteers received single doses of 30 mg nadolol orally with water (control), or an aqueous solution of EGCG-concentrated green tea extract (GTE) at low or high dose. Plasma concentrations and urinary excretion of nadolol were determined up to 48 h. In addition, blood pressure and pulse rate were monitored. In vitro transport kinetic experiments were performed using human embryonic kidney 293 cells stably expressing organic anion transporting polypeptide (OATP)1A2 to evaluate the inhibitory effect of EGCG on OATP1A2-mediated substrate transport.
RESULTS: Single coadministration of low and high dose GTE significantly reduced the plasma concentrations of nadolol. The geometric mean ratios with 90% CI for area under the plasma concentration-time curves from 0 to infinity of nadolol were 0.72 (0.56-0.87) for the low and 0.60 (0.51-0.69) for the high dose. There were no significant differences in Tmax, elimination half-life, and renal clearance between GTE and water phases. No significant changes were observed for blood pressure and pulse rate between phases. EGCG competitively inhibited OATP1A2-mediated uptake of sulphobromophthalein and nadolol with Ki values of 21.6 and 19.4 μM, respectively.
CONCLUSIONS: EGCG is suggested to be a key contributor to the interaction of green tea with nadolol. Moreover, even a single coadministration of green tea may significantly affect nadolol pharmacokinetics.


FAU Authors / FAU Editors

Fromm, Martin Prof. Dr.
Lehrstuhl für Klinische Pharmakologie und Klinische Toxikologie


External institutions with authors

Fukushima Medical University / 福島県立医科大学
Shizuoka University / 静岡大学


How to cite

APA:
Abe, O., Ono, T., Sato, H., Mueller, F., Ogata, H., Miura, I.,... Misaka, S. (2018). Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers. European Journal of Clinical Pharmacology, 74(6), 775-783. https://dx.doi.org/10.1007/s00228-018-2436-2

MLA:
Abe, Osamu, et al. "Role of (-)-epigallocatechin gallate in the pharmacokinetic interaction between nadolol and green tea in healthy volunteers." European Journal of Clinical Pharmacology 74.6 (2018): 775-783.

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Last updated on 2018-07-11 at 08:23