Radiochemotherapy of bladder cancer. An alternative to radical cystectomy
Rodel C, Ott O, Weiss C (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 24
Pages Range: 40-47
Journal Issue: 1
Abstract
Background. The standard treatment of muscle invasive carcinoma is cystectomy with pelvic lymphadenectomy. The primary organ-preserving, trimodal therapy is considered an alternative to radical surgery. Objective. The concept and results of trimodal therapy, consisting of initial transurethral resection of the bladder tumor (TUR-B) followed by simultaneous radiochemotherapy (RCT) are presented. Material and methods. Evaluation of retrospective cohorts and prospective therapy optimization studies on organ preservation regimens. Comparative meta-analyses comparing cystectomy with trimodal treatment are presented. Results. A complete TUR-B including bladder mapping and tumor ground biopsy should be carried out before RCT. Radio-sensitization should be cisplatin-based or with a combination of 5-fluorouracil and mitomycin C. Complete response rates after TUR-B plus RCT are achieved in 60-90% of patients as well as 5-year survival rates between 40% and 75% and with preservation of the bladder in approximately 80% of surviving patients. Conclusion. Trimodal therapy is a viable alternative to radical cystectomy with curative intention for patients with muscle invasive urinary bladder carcinoma. Patients with early stage tumors (cT2/3N0) are particularly suitable in whom the initial TUR-B leads to as complete a tumor resection as possible (R0).
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Rodel, C., Ott, O., & Weiss, C. (2018). Radiochemotherapy of bladder cancer. An alternative to radical cystectomy. Onkologe, 24(1), 40-47.
MLA:
Rodel, C., O. Ott, and C. Weiss. "Radiochemotherapy of bladder cancer. An alternative to radical cystectomy." Onkologe 24.1 (2018): 40-47.
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