Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade

Journal article


Publication Details

Author(s): Podolska M, Mahajan A, Knopf J, Boeltz S, Munoz LE, Bilyy R, Hahn J, Herrmann M
Journal: Autoimmunity
Publication year: 2018
Pages range: 1-7
ISSN: 0891-6934


Abstract

Rheumatic diseases are a group of inflammatory conditions that affect joints and connective tissues and are often accompanied by pain and restriction of motility. In many of these diseases, autoantibodies develop that react with molecules/structures commonly found hidden in neutrophils. Neutrophil extracellular trap (NET) formation and release is considered a defense mechanism against pathogens or endogenous danger signals and it has been associated with initial inflammatory responses. NETs are also endowed with an important resolution potential based on its intrinsic enzymatic activity, but in the case they are not timely removed from the crime scene they might modulate subsequent immune responses and contribute to the pathogenesis of chronic inflammatory diseases. In this review, we will summarize the actual knowledge about the multifaceted roles of NETs in the etiology and pathogenesis of rheumatic autoimmune diseases.


FAU Authors / FAU Editors

Hahn, Jonas
Medizinische Klinik 3 - Rheumatologie und Immunologie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Knopf, Jasmin
Medizinische Klinik 3 - Rheumatologie und Immunologie
Medizinische Klinik 3 - Rheumatologie und Immunologie
Mahajan, Aparna
Podolska, Malgorzata
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions
Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького


How to cite

APA:
Podolska, M., Mahajan, A., Knopf, J., Boeltz, S., Munoz, L.E., Bilyy, R.,... Herrmann, M. (2018). Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade. Autoimmunity, 1-7. https://dx.doi.org/10.1080/08916934.2018.1519804

MLA:
Podolska, Malgorzata, et al. "Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade." Autoimmunity (2018): 1-7.

BibTeX: 

Last updated on 2018-26-11 at 08:53