Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autor(en): Podolska M, Mahajan A, Knopf J, Boeltz S, Munoz LE, Bilyy R, Hahn J, Herrmann M
Zeitschrift: Autoimmunity
Jahr der Veröffentlichung: 2018
Seitenbereich: 1-7
ISSN: 0891-6934


Abstract

Rheumatic diseases are a group of inflammatory conditions that affect joints and connective tissues and are often accompanied by pain and restriction of motility. In many of these diseases, autoantibodies develop that react with molecules/structures commonly found hidden in neutrophils. Neutrophil extracellular trap (NET) formation and release is considered a defense mechanism against pathogens or endogenous danger signals and it has been associated with initial inflammatory responses. NETs are also endowed with an important resolution potential based on its intrinsic enzymatic activity, but in the case they are not timely removed from the crime scene they might modulate subsequent immune responses and contribute to the pathogenesis of chronic inflammatory diseases. In this review, we will summarize the actual knowledge about the multifaceted roles of NETs in the etiology and pathogenesis of rheumatic autoimmune diseases.


FAU-Autoren / FAU-Herausgeber

Hahn, Jonas
Medizinische Klinik 3 - Rheumatologie und Immunologie
Herrmann, Martin Prof. Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Knopf, Jasmin
Medizinische Klinik 3 - Rheumatologie und Immunologie
Mahajan, Aparna
Medizinische Klinik 3 - Rheumatologie und Immunologie
Podolska, Malgorzata
Medizinische Klinik 3 - Rheumatologie und Immunologie


Autor(en) der externen Einrichtung(en)
Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького


Zitierweisen

APA:
Podolska, M., Mahajan, A., Knopf, J., Boeltz, S., Munoz, L.E., Bilyy, R.,... Herrmann, M. (2018). Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade. Autoimmunity, 1-7. https://dx.doi.org/10.1080/08916934.2018.1519804

MLA:
Podolska, Malgorzata, et al. "Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade." Autoimmunity (2018): 1-7.

BibTeX: 

Zuletzt aktualisiert 2018-26-11 um 08:53