Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade
Podolska M, Mahajan A, Knopf J, Hahn J, Boeltz S, Munoz LE, Bilyy R, Herrmann M (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Pages Range: 1-7
DOI: 10.1080/08916934.2018.1519804
Abstract
Rheumatic diseases are a group of inflammatory conditions that affect joints and connective tissues and are often accompanied by pain and restriction of motility. In many of these diseases, autoantibodies develop that react with molecules/structures commonly found hidden in neutrophils. Neutrophil extracellular trap (NET) formation and release is considered a defense mechanism against pathogens or endogenous danger signals and it has been associated with initial inflammatory responses. NETs are also endowed with an important resolution potential based on its intrinsic enzymatic activity, but in the case they are not timely removed from the crime scene they might modulate subsequent immune responses and contribute to the pathogenesis of chronic inflammatory diseases. In this review, we will summarize the actual knowledge about the multifaceted roles of NETs in the etiology and pathogenesis of rheumatic autoimmune diseases.
Authors with CRIS profile
Malgorzata Podolska
Department of Medicine 3 – Rheumatology and Immunology
Aparna Mahajan
Department of Medicine 3 – Rheumatology and Immunology
Jasmin Knopf
Department of Medicine 3 – Rheumatology and Immunology
Jonas Hahn
Department of Medicine 3 – Rheumatology and Immunology
Luis Munoz Becerra
Department of Medicine 3 – Rheumatology and Immunology
Martin Herrmann
Department of Medicine 3 – Rheumatology and Immunology
Involved external institutions
Ukraine (UA)How to cite
APA:
Podolska, M., Mahajan, A., Knopf, J., Hahn, J., Boeltz, S., Munoz, L.E.,... Herrmann, M. (2018). Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade. Autoimmunity, 1-7. https://dx.doi.org/10.1080/08916934.2018.1519804
MLA:
Podolska, Malgorzata, et al. "Autoimmune, rheumatic, chronic inflammatory diseases: Neutrophil extracellular traps on parade." Autoimmunity (2018): 1-7.
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