Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis

Chen Z, Bozec A, Schett G, Ramming A (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Nature Reviews Rheumatology Nature Publishing Group

DOI: 10.1038/s41584-018-0109-2

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and mediators that trigger RA have been the focus of intense investigations, the regulatory and anti-inflammatory cytokines responsible for the suppression and resolution of disease in a context-dependent manner have been less well characterized. However, knowledge of the pathways that control the suppression and resolution of inflammation in RA is clinically relevant and conceptually important for understanding the pathophysiology of the disease and for the development of treatments that enable long-term remission. Cytokine-mediated processes such as the activation of T helper 2 cells by IL-4 and IL-13, the resolution of inflammation by IL-9, IL-5-induced eosinophil expansion, IL-33-mediated macrophage polarization, the production of IL-10 by regulatory B cells and IL-27-mediated suppression of lymphoid follicle formation are all involved in governing the regulation and resolution of inflammation in RA. By better understanding these immune-regulatory signalling pathways, new therapeutic strategies for RA can be envisioned that aim to balance and resolve, rather than suppress, inflammation.

Authors with CRIS profile

Aline Bozec Juniorprofessur für Osteoimmunologie Georg Schett Lehrstuhl für Innere Medizin III Andreas Ramming Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

University of Science and Technology of China (USTC) CN China (CN)

How to cite

APA:

Chen, Z., Bozec, A., Schett, G., & Ramming, A. (2018). Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nature Reviews Rheumatology. https://dx.doi.org/10.1038/s41584-018-0109-2

MLA:

Chen, Zhu, et al. "Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis." Nature Reviews Rheumatology (2018).

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