Association of an In-House Blood Bank with Therapy and Outcome in Severely Injured Patients: An Analysis of 18,573 Patients from the TraumaRegister DGU®

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Details zur Publikation

Autor(en): Debus F, Lefering R, Lechler P, Schwarting T, Bockmann B, Strasser E, Mand C, Ruchholtz S, Frink M
Zeitschrift: PLoS ONE
Jahr der Veröffentlichung: 2016
Band: 11
Heftnummer: 11
ISSN: 1932-6203


Abstract

INTRODUCTION: Hemorrhagic shock remains one of the most common causes of death in severely injured patients. It is unknown to what extent the presence of a blood bank in a trauma center influences therapy and outcome in such patients.
MATERIAL AND METHODS: We retrospectively analyzed prospectively recorded data from the TraumaRegister DGU® and the TraumaNetzwerk DGU®. Inclusion criteria were Injury Severity Score (ISS) ≥ 16, primarily treated patients, and hospital admission 2 years before or after the audit process.
RESULTS: Complete data sets of 18,573 patients were analyzed. Of 457 hospitals included, 33.3% had an in-house blood bank. In trauma centers with a blood bank (HospBB), packed red blood cells (PRBCs) (21.0% vs. 17.4%, p < 0.001) and fresh frozen plasma (FFP) (13.9% vs. 10.2%, p <0.001) were transfused significantly more often than in hospitals without a blood bank (Hosp0). However, no significant difference was found for in-hospital mortality (standard mortality ratio [SMR, 0.907 vs. 0.945; p = 0.25). In patients with clinically apparent shock on admission, no difference of performed transfusions were present between HospBB and Hosp0 (PRBCs, 51.4% vs. 50.4%, p = 0.67; FFP, 32.7% vs. 32.7%, p = 0.99), and no difference in in-hospital mortality was observed (SMR, 0.907 vs. 1.004; p = 0.21).
DISCUSSION: In HospBB transfusions were performed more frequently in severely injured patients without positively affecting the 24h mortality or in-house mortality. Easy access may explain a more liberal transfusion concept.


FAU-Autoren / FAU-Herausgeber

Strasser, Erwin Prof. Dr.
Medizinische Fakultät


Zusätzliche Organisationseinheit(en)
Transfusionsmedizinische und Hämostaseologische Abteilung in der Chirurgischen Klinik


Autor(en) der externen Einrichtung(en)
Private Universität Witten/Herdecke gGmbH
Universitätsklinikum Gießen und Marburg (UKGM)


Zitierweisen

APA:
Debus, F., Lefering, R., Lechler, P., Schwarting, T., Bockmann, B., Strasser, E.,... Frink, M. (2016). Association of an In-House Blood Bank with Therapy and Outcome in Severely Injured Patients: An Analysis of 18,573 Patients from the TraumaRegister DGU®. PLoS ONE, 11(11). https://dx.doi.org/10.1371/journal.pone.0148736

MLA:
Debus, Florian, et al. "Association of an In-House Blood Bank with Therapy and Outcome in Severely Injured Patients: An Analysis of 18,573 Patients from the TraumaRegister DGU®." PLoS ONE 11.11 (2016).

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Zuletzt aktualisiert 2018-07-11 um 13:12