Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention

Benz K, Schlote J, Daniel C, Kopp C, Dahlmann A, Schröder A, Cordasic N, Klanke B, Hilgers KF, Titze J, Amann KU (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Kidney & Blood Pressure Research Karger

Book Volume: 43

Pages Range: 1-11

Journal Issue: 1

DOI: 10.1159/000486734

Abstract

BACKGROUND/AIMS: One potential pathomechanism how low nephron number leads to hypertension in later life is altered salt handling. We therefore evaluated changes in electrolyte and water content in wildtype (wt) and GDNF+/- mice with a 30% reduction of nephron number. METHODS: 32 GDNF+/- and 36 wt mice were fed with low salt (LSD, 0.03%, normal drinking water) or high salt (HSD, 4%, 0.9% drinking water) diet for 4 weeks. Blood pressure was continuously measured by telemetry in a subgroup. At the end of the experiment and after standardized ashing processes electrolyte- and water contents of the skin and the total body were determined. RESULTS: We found higher blood pressure in high salt treated GDNF+/-compared to wt mice. Of interest, we could not confirm an increase in total-body sodium as predicted by prevailing explanations, but found increased total body and skin chloride that interestingly correlated with relative kidney weight. CONCLUSION: We hereby firstly report significant total body and skin chloride retention in salt sensitive hypertension of GDNF+/-mice with genetically determined lower nephron number. Thus, in contrast to the prevailing opinion our data argue for the involvement of non-volume related mechanisms.

Authors with CRIS profile

Kerstin Benz Medizinische Fakultät Julia Schlote Department of Nephropathology Christoph Daniel Department of Nephropathology Agnes Schröder Interdisziplinäres Zentrum für Klinische Forschung IZKF-Förderlinien Karl Friedrich Hilgers Professur für Innere Medizin (Hochdruckforschung) Kerstin Ute Amann Department of Nephropathology

Involved external institutions

Vanderbilt University US United States (USA) (US)

How to cite

APA:

Benz, K., Schlote, J., Daniel, C., Kopp, C., Dahlmann, A., Schröder, A.,... Amann, K.U. (2018). Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention. Kidney & Blood Pressure Research, 43(1), 1-11. https://dx.doi.org/10.1159/000486734

MLA:

Benz, Kerstin, et al. "Mild Salt-Sensitive Hypertension in Genetically Determined Low Nephron Number is Associated with Chloride but Not Sodium Retention." Kidney & Blood Pressure Research 43.1 (2018): 1-11.

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