Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles

Kremer A, Zonneveld MI, Kremer AE, Van Der Meijden ED, Falkenburg JHF, Wauben MHM, Nolte-'T Hoen ENM, Griffioen M (2018)

Publication Type: Journal article

Publication year: 2018

Journal

European Journal of Immunology Wiley-VCH Verlag

DOI: 10.1002/eji.201747152

Abstract

CD4 T-cells play a central role as helper cells in adaptive immunity. Presentation of exogenous antigens in MHC class II by professional antigen-presenting cells is a crucial step in induction of specific CD4 T-cells in adaptive immune responses. For efficient induction of immunity against intracellular threats such as viruses or malignant transformations, antigens from HLA class II-negative infected or transformed cells need to be transferred to surrounding antigen-presenting cells to allow efficient priming of naive CD4 T-cells. Here we show indirect antigen presentation for a subset of natural HLA class II ligands that are created by genetic variants and demonstrated that (neo)antigens can be transferred between cells by extracellular vesicles. Intercellular transfer by extracellular vesicles was not dependent on the T-cell epitope, but rather on characteristics of the full-length protein. This mechanism of (neo)antigen transfer from HLA class II-negative cells to surrounding antigen-presenting cells may play a crucial role in induction of anti-tumor immunity. This article is protected by copyright. All rights reserved.

Authors with CRIS profile

Anita Kremer Department of Medicine 5 – Haematology and Oncology

Involved external institutions

University of Amsterdam NL Netherlands (NL) Leiden University NL Netherlands (NL) Universiteit Utrecht (UU) / Utrecht University NL Netherlands (NL)

How to cite

APA:

Kremer, A., Zonneveld, M.I., Kremer, A.E., Van Der Meijden, E.D., Falkenburg, J.H.F., Wauben, M.H.M.,... Griffioen, M. (2018). Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles. European Journal of Immunology. https://dx.doi.org/10.1002/eji.201747152

MLA:

Kremer, Anita, et al. "Natural T-cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles." European Journal of Immunology (2018).

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