A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin

Simon D, Kleyer A, Englbrecht M, Stemmler F, Simon C, Berlin A, Kocijan R, Haschka J, Hirschmann S, Atreya R, Neurath M, Sticherling M, Rech J, Hueber A, Engelke K, Schett G (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Bone Elsevier

Book Volume: 116

Pages Range: 87-93

DOI: 10.1016/j.bone.2018.07.017

Abstract

Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now allow the accurate measure of articular bone composition. In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand. Metacarpal heads were assessed for total, trabecular and cortical volumetric bone mineral density (vBMD). Only ACPA+RA, but not the remaining inflammatory diseases (ACPA-RA, CD, UC, PsO, PsA) showed significant (p < 0.001) loss of articular bone affecting both the trabecular and the cortical compartments. Age and body mass index were also associated with articular bone changes, the former with lower, the latter with higher articular bone mass. In multivariate models, presence of ACPA+RA was an independent factor for articular bone loss. Among chronic inflammatory diseases ACPA+RA is the most potent precipitator for articular bone loss pointing out the role of autoimmunity in the development of articular bone disease in the context of chronic inflammatory disease.

Authors with CRIS profile

David Simon Lehrstuhl für Innere Medizin III Arnd Kleyer Lehrstuhl für Innere Medizin III Matthias Englbrecht Lehrstuhl für Innere Medizin III Andreas Berlin Lehrstuhl für Innere Medizin III Raja Atreya Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur) Markus Neurath Lehrstuhl für Innere Medizin I Michael Sticherling Professur für Dermatologie Hans Jürgen Rech Department of Medicine 3 – Rheumatology and Immunology Axel Hueber Department of Medicine 3 – Rheumatology and Immunology Klaus Engelke Lehrstuhl für Medizinische Physik und Mikrogewebetechnik Georg Schett Lehrstuhl für Innere Medizin III

Involved external institutions

Medizinische Universität Wien AT Austria (AT)

How to cite

APA:

Simon, D., Kleyer, A., Englbrecht, M., Stemmler, F., Simon, C., Berlin, A.,... Schett, G. (2018). A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin. Bone, 116, 87-93. https://doi.org/10.1016/j.bone.2018.07.017

MLA:

Simon, David, et al. "A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin." Bone 116 (2018): 87-93.

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