A novel human artery model to assess the magnetic accumulation of SPIONs under flow conditions

Janikowska A, Matuszak J, Lyer S, Schreiber E, Unterweger H, Zaloga J, Groll J, Alexiou C, Cicha I (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 7

DOI: 10.1038/srep42314

Abstract

Magnetic targeting utilises the properties of superparamagnetic iron oxide nanoparticles (SPIONs) to accumulate particles in specified vasculature regions under an external magnetic field. As the behaviour of circulating particles varies depending on nanoparticle characteristics, magnetic field strength and flow dynamics, we established an improved ex vivo model in order to estimate the magnetic capture of SPIONs in physiological-like settings. We describe here a new, easy to handle ex vivo model of human umbilical artery. Using this model, the magnetic targeting of different types of SPIONs under various external magnetic field gradients and flow conditions was investigated by atomic emission spectroscopy and histology. Among tested particles, SPION-1 with lauric acid shell had the largest capacity to accumulate at the specific artery segment. SPION-2 (lauric acid/albumin-coated) were also successfully targeted, although the observed peak in the iron content under the tip of the magnet was smaller than for SPION-1. In contrast, we did not achieve magnetic accumulation of dextran-coated SPION-3. Taken together, the umbilical artery model constitutes a time- and cost-efficient, 3R-compliant tool to assess magnetic targeting of SPIONs under flow. Our results further imply the possibility of an efficient in vivo targeting of certain types of SPIONs to superficial arteries.

Authors with CRIS profile

Jasmin Matuszak Department of Otorhinolaryngology – Head and Neck Surgery Stefan Lyer Department of Otorhinolaryngology – Head and Neck Surgery Harald Unterweger Department of Otorhinolaryngology – Head and Neck Surgery Jan Zaloga Department of Otorhinolaryngology – Head and Neck Surgery Christoph Alexiou Professur für Nanomedizin Iwona Cicha Lehrstuhl für Innere Medizin II

Involved external institutions

Universitätsklinikum Würzburg DE Germany (DE)

How to cite

APA:

Janikowska, A., Matuszak, J., Lyer, S., Schreiber, E., Unterweger, H., Zaloga, J.,... Cicha, I. (2017). A novel human artery model to assess the magnetic accumulation of SPIONs under flow conditions. Scientific Reports, 7. https://doi.org/10.1038/srep42314

MLA:

Janikowska, Agata, et al. "A novel human artery model to assess the magnetic accumulation of SPIONs under flow conditions." Scientific Reports 7 (2017).

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