Automated setup for ex vivo larynx experiments

Journal article

Publication Details

Author(s): Birk V, Döllinger M, Sutor A, Berry DA, Gedeon D, Traxdorf M, Wendler O, Bohr C, Kniesburges S
Journal: Journal of the Acoustical Society of America
Publication year: 2017
Volume: 141
Journal issue: 3
Pages range: 1349-1359
ISSN: 0001-4966


Ex vivo larynx experiments are limited in time due to degeneration of the laryngeal tissues. In order to acquire a significant and comparable amount of data, automatization of current manual experimental procedures is desirable. A computer controlled, electro-mechanical setup was developed for time-dependent variation of specific physiological parameters, including adduction and elongation level of the vocal folds and glottal flow. The setup offers a standardized method to induce defined forces on the laryngeal cartilages. Furthermore, phonation onset is detected automatically and the subsequent measurement procedure is automated and standardized to improve the efficiency of the experimental process. The setup was validated using four ex vivo porcine larynges, whereas each validation measurement series was executed with one separate larynx. Altogether 31 single measurements were undertaken, which can be summed up to a total experimental time of about 4 min. Vocal fold elongation and adduction lead both to an increase in fundamental frequency and subglottal pressure. Measurement procedures like applying defined subglottal pressure steps and onset-offset detection were reliably executed. The setup allows for a computer-based parameter control, which enables fast experimental execution over a wide range of laryngeal configurations. This maximizes the number of measurements and reduces personal effort compared with manual procedures.

FAU Authors / FAU Editors

Birk, Veronika
Phoniatrische und Pädaudiologische Abteilung in der Hals-Nasen-Ohren-Klinik
Bohr, Christopher PD Dr.
Professur für Laryngologie
Döllinger, Michael Prof. Dr.
Professur für Computational Medicine (DFG-Forschungsprofessur)
Gedeon, Dominik
Lehrstuhl für Sensorik
Kniesburges, Stefan PD Dr.-Ing.
Phoniatrische und Pädaudiologische Abteilung in der Hals-Nasen-Ohren-Klinik
Sutor, Alexander Dr.-Ing.
Lehrstuhl für Sensorik

External institutions with authors

University of California Los Angeles (UCLA)

How to cite

Birk, V., Döllinger, M., Sutor, A., Berry, D.A., Gedeon, D., Traxdorf, M.,... Kniesburges, S. (2017). Automated setup for ex vivo larynx experiments. Journal of the Acoustical Society of America, 141(3), 1349-1359.

Birk, Veronika, et al. "Automated setup for ex vivo larynx experiments." Journal of the Acoustical Society of America 141.3 (2017): 1349-1359.


Last updated on 2018-05-11 at 15:08