Real world experience in low-dose ipilimumab in combination with PD-1 blockade in advanced melanoma patients

Journal article


Publication Details

Author(s): Kirchberger MC, Moreira A, Erdmann M, Schuler G, Heinzerling L
Journal: Oncotarget
Publication year: 2018
Volume: 9
Journal issue: 48
Pages range: 28903-28909
ISSN: 1949-2553


Abstract

Dual immune-checkpoint blockade with the anti-PD-1 antibody nivolumab (1 mg/kg) and standard-dose ipilimumab (3 mg/kg) is the mainstay of immunotherapy in advanced melanoma and it is approved since 2016. However, severe side effects (grade 3/4) occur in up to 60% of the patients. Recently, clinical trials have shown similar anti-tumor activity with a more favorable toxicity profile in patients treated with low-dose ipilimumab (1 mg/kg) and standard-dose pembrolizumab (2 mg/kg). In this study we report on the real-world experience of this dosing regime in advanced melanoma patients not eligible for clinical trials. A total of 33 patients with metastatic melanoma (24 with cutaneous and 9 with uveal melanoma) were assessed, retrospectively. Brain metastases were present in 33% of the patients and lactate dehydrogenase was elevated in 70%. Overall response rates were 38% and 0% in cutaneous melanoma and uveal melanoma respectively. Median overall survival was not reached in cutaneous melanoma and was 18 months in uveal melanoma. In 18% of the patients at least one treatment-related severe adverse event was observed. Our observation that the combination of standard dose pembrolizumab and low-dose ipilimumab has a favorable toxicity profile yet anti-tumor activity comparable to the approved standard-dose combination regime in advanced patients not suitable for enrollment in clinical trials is encouraging.


FAU Authors / FAU Editors

Heinzerling, Lucie Prof. Dr.
Hautklinik
Moreira, Alvaro Dr. med.
Hautklinik
Schuler, Gerold Prof. Dr.
Lehrstuhl für Haut- und Geschlechtskrankheiten


How to cite

APA:
Kirchberger, M.C., Moreira, A., Erdmann, M., Schuler, G., & Heinzerling, L. (2018). Real world experience in low-dose ipilimumab in combination with PD-1 blockade in advanced melanoma patients. Oncotarget, 9(48), 28903-28909. https://dx.doi.org/10.18632/oncotarget.25627

MLA:
Kirchberger, Michael Constantin, et al. "Real world experience in low-dose ipilimumab in combination with PD-1 blockade in advanced melanoma patients." Oncotarget 9.48 (2018): 28903-28909.

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Last updated on 2019-25-04 at 14:57