Meningioma growth dynamics assessed by radiocarbon retrospective birth dating
Huttner HB, Bergmann O, Salehpour M, El Cheikh R, Nakamura M, Tortora A, Heinke P, Coras R, Englund E, Eyüpoglu IY, Kuramatsu J, Röder S, Kloska S, Mühlen I, Dörfler A, Schwab S, Possnert G, Bernard S, Frisen J (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 27
Pages Range: 176-181
DOI: 10.1016/j.ebiom.2017.12.020
Abstract
It is not known how long it takes from the initial neoplastic transformation of a cell to the detection of a tumor, which would be valuable for understanding tumor growth dynamics. Meningiomas show a broad histological, genetic and clinical spectrum, are usually benign and considered slowly growing. There is an intense debate regarding their age and growth pattern and when meningiomas should be resected. We have assessed the age and growth dynamics of 14 patients with meningiomas (WHO grade I: n=6 with meningothelial and n=6 with fibrous subtype, as well as n=2 atypical WHO grade II meningiomas) by combining retrospective birth-dating of cells by analyzing incorporation of nuclear-bomb-test-derived 14C, analysis of cell proliferation, cell density, MRI imaging and mathematical modeling. We provide an integrated model of the growth dynamics of benign meningiomas. The mean age of WHO grade I meningiomas was 22.1±6.5years, whereas atypical WHO grade II meningiomas originated 1.5±0.1years prior to surgery (p<0.01). We conclude that WHO grade I meningiomas are very slowly growing brain tumors, which are resected in average two decades after time of origination.
Authors with CRIS profile
Ilker Yasin Eyüpoglu
Department of Neurosurgery
Joji Kuramatsu
Lehrstuhl für Neurologie
Sebastian Röder
Department of Neurology
Stephan Kloska
Department of Neuroradiology
Iris Mühlen
Department of Neuroradiology
Arnd Dörfler
Department of Neuroradiology
Stefan Schwab
Lehrstuhl für Neurologie
Involved external institutions
Skåne University Hospital / Skånes universitetssjukhus
Sweden (SE)
Karolinska Institute
Sweden (SE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
Uppsala University
Sweden (SE)
Technische Universität Dresden
Germany (DE)
Aix-Marseille University / Aix-Marseille Université
France (FR)
Sweden (SE)
Karolinska Institute
Sweden (SE)
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Germany (DE)
Université Claude Bernard Lyon 1 (UCB)
France (FR)
Uppsala University
Sweden (SE)
Technische Universität Dresden
Germany (DE)
Aix-Marseille University / Aix-Marseille Université
France (FR)
How to cite
APA:
Huttner, H.B., Bergmann, O., Salehpour, M., El Cheikh, R., Nakamura, M., Tortora, A.,... Frisen, J. (2018). Meningioma growth dynamics assessed by radiocarbon retrospective birth dating. EBioMedicine, 27, 176-181. https://doi.org/10.1016/j.ebiom.2017.12.020
MLA:
Huttner, Hagen B., et al. "Meningioma growth dynamics assessed by radiocarbon retrospective birth dating." EBioMedicine 27 (2018): 176-181.
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