rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Liu J, Loncar I, Collee JM, Bolla MK, Dennis J, Michailidou K, Wang Q, Andrulis IL, Barile M, Beckmann M, Behrens S, Benitez J, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Brauch H, Brennan P, Brenner H, Broeks A, Burwinkel B, Chang-Claude J, Chen ST, Chenevix-Trench G, Cheng CY, Choi JY, Couch FJ, Cox A, Cross SS, Cuk K, Czene K, Doerk T, Dos-Santos-Silva I, Fasching P, Figueroa J, Flyger H, Garcia-Closas M, Giles GG, Glendon G, Goldberg MS, Gonzalez-Neira A, Guenel P, Haiman CA, Hamann U, Hart SN, Hartman M, Hatse S, Hopper JL, Ito H, Jakubowska A, Kabisch M, Kang D, Kosma VM, Kristensen VN, Le Marchand L, Lee E, Li J, Lophatananon A, Lubinski J, Mannermaa A, Matsuo K, Milne RL, Neuhausen SL, Nevanlinna H, Orr N, Perez JIA, Peto J, Putti TC, Pylkas K, Radice P, Sangrajrang S, Sawyer EJ, Schmidt MK, Schneeweiss A, Shen CY, Shrubsole MJ, Shu XO, Simard J, Southey MC, Swerdlow A, Teo SH, Tessier DC, Thanasitthichai S, Tomlinson I, Torres D, Truong T, Tseng CC, Vachon C, Winqvist R, Wu AH, Yannoukakos D, Zheng W, Hall P, Dunning AM, Easton DF, Hooning MJ, Van Den Ouweland AMW, Martens JWM, Hollestelle A
Zeitschrift: Scientific Reports
Jahr der Veröffentlichung: 2016
Band: 6
ISSN: 2045-2322


NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe

Einrichtungen weiterer Autorinnen und Autoren

Aichi Cancer Center Research Institute
Antoni van Leeuwenhoek
Cancer Council Victoria
Cancer Research Initiatives Foundation (CARIF)
Changhua Christian Hospital
China Medical University (CMU) / 中國醫藥大學
City of Hope Medical Center
Copenhagen University Hospital
Deutsches Krebsforschungszentrum (DKFZ)
École Polytechnique - Université Paris-Saclay
Erasmus University Medical Center
Erasmus University Rotterdam (EUR) / Erasmus Universiteit Rotterdam
European Institute of Oncology / Istituto Europeo di Oncologia (IEO)
Flanders Institute for Biotechnology / Vlaams Instituut voor Biotechnologie (VIB)
Helsingin yliopisto / University of Helsinki
Hospital Monte Naranco
International Agency for Research on Cancer (IARC)
Istituto di ricovero e cura a carattere scientifico (IRCCS)
Karolinska Institute
King’s College London
London School of Hygiene and Tropical Medicine
Mayo Clinic
McGill University
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Mount Sinai Hospital (MSH)
Nagoya University / 名古屋大学
National Cancer Institute (NCI)
National Centre for Scientific Research (NCSR) "Demokritos"
National University of Singapore (NUS)
Oslo University Hospital / Oslo Universitetssykehus
Oulun Yliopisto / University of Oulo
Pomeranian Medical University / Pomorski Uniwersytet Medyczny w Szczecinie (PMU)
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Ruprecht-Karls-Universität Heidelberg
Seoul National University (SNU) / 서울대학교
Singapore National Eye Centre (SNEC)
Spanish National Cancer Research Centre / Centro Nacional de Investigaciones Oncológicas (CNIO)
The Institute of Cancer Research (ICR)
The University of Melbourne
Université Laval (UL)
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of Cambridge
University of Eastern Finland
University of Edinburgh
University of Hawaii (U.H.)
University of Oxford
University of Sheffield
University of Southern California (USC)
University of Warwick
Vanderbilt University


Liu, J., Loncar, I., Collee, J.M., Bolla, M.K., Dennis, J., Michailidou, K.,... Hollestelle, A. (2016). rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. Scientific Reports, 6.

Liu, Jingjing, et al. "rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk." Scientific Reports 6 (2016).


Zuletzt aktualisiert 2019-28-02 um 06:24