Innovative Methods and Applications in Mucoadhesion Research
Mackie AR, Goycoolea FM, Menchicchi B, Caramella CM, Saporito F, Lee S, Stephansen K, Chronakis IS, Hiorth M, Adamczak M, Waldner M, Nielsen HM, Marcelloni L (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 17
Journal Issue: 8
Abstract
The present review is aimed at elucidating relatively new aspects of mucoadhesion/mucus interaction and related phenomena that emerged from a Mucoadhesion workshop held in Munster on 2-3 September 2015 as a satellite event of the ICCC 13th-EUCHIS 12th. After a brief outline of the new issues, the focus is on mucus description, purification, and mucus/mucin characterization, all steps that are pivotal to the understanding of mucus related phenomena and the choice of the correct mucosal model for in vitro and ex vivo experiments, alternative bio/mucomimetic materials are also presented. Then a selection of preparative techniques and testing methods are described (at molecular as well as micro and macroscale) that may support the pharmaceutical development of mucus interactive systems and assist formulators in the scale-up and industrialization steps. Recent applications of mucoadhesive systems (including medical devices) intended for different routes of administration (oral, gastrointestinal, vaginal, nasal, ocular, and intravesical) and for the treatment of difficult to treat pathologies or the alleviation of symptoms are described.
Authors with CRIS profile
Bianca Menchicchi
Erlangen Graduate School in Advanced Optical Technologies
Maximilian Waldner
Lehrstuhl für Innere Medizin I
Involved external institutions
University of East Anglia
United Kingdom (GB)
University of Leeds
United Kingdom (GB)
Università degli Studi di Pavia
Italy (IT)
Technical University of Denmark / Danmarks Tekniske Universitet (DTU)
Denmark (DK)
University of Oslo
Norway (NO)
University of Copenhagen
Denmark (DK)
S.I.I.T. S.r.l.
Italy (IT)
United Kingdom (GB)
University of Leeds
United Kingdom (GB)
Università degli Studi di Pavia
Italy (IT)
Technical University of Denmark / Danmarks Tekniske Universitet (DTU)
Denmark (DK)
University of Oslo
Norway (NO)
University of Copenhagen
Denmark (DK)
S.I.I.T. S.r.l.
Italy (IT)
How to cite
APA:
Mackie, A.R., Goycoolea, F.M., Menchicchi, B., Caramella, C.M., Saporito, F., Lee, S.,... Marcelloni, L. (2017). Innovative Methods and Applications in Mucoadhesion Research. Macromolecular Bioscience, 17(8). https://dx.doi.org/10.1002/mabi.201600534
MLA:
Mackie, Alan R., et al. "Innovative Methods and Applications in Mucoadhesion Research." Macromolecular Bioscience 17.8 (2017).
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