Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives
Waldner M, Rath T, Schürmann S, Bojarski C, Atreya R (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 8
Abstract
In recent years, various technological developments markedly improved imaging of mucosal inflammation in patients with inflammatory bowel diseases. Although technological developments such as high-definition-, chromo-, and autofluorescence-endoscopy led to a more precise and detailed assessment of mucosal inflammation during wide-field endoscopy, probe-based and stationary confocal laser microscopy enabled in vivo real-time microscopic imaging of mucosal surfaces within the gastrointestinal tract. Through the use of fluorochromes with specificity against a defined molecular target combined with endoscopic techniques that allow ultrastructural resolution, molecular imaging enables in vivo visualization of single molecules or receptors during endoscopy. Molecular imaging has therefore greatly expanded the clinical utility and applications of modern innovative endoscopy, which include the diagnosis, surveillance, and treatment of disease as well as the prediction of the therapeutic response of individual patients. Furthermore, non-invasive imaging techniques such as computed tomography, magnetic resonance imaging, scintigraphy, and ultrasound provide helpful information as supplement to invasive endoscopic procedures. In this review, we provide an overview on the current status of advanced imaging technologies for the clinical non-invasive and endoscopic evaluation of mucosal inflammation. Furthermore, the value of novel methods such as multiphoton microscopy, optoacoustics, and optical coherence tomography and their possible future implementation into clinical diagnosis and evaluation of mucosal inflammation will be discussed.
Authors with CRIS profile
Maximilian Waldner
Professur für Funktionelle Bildgebung in der Medizin
Sebastian Schürmann
Lehrstuhl für Medizinische Biotechnologie
Raja Atreya
Professur für Translationale Immunforschung bei chronisch entzündlichen Darmerkrankungen (Heisenberg-Professur)
Related research project(s)
Involved external institutions
Germany (DE)How to cite
APA:
Waldner, M., Rath, T., Schürmann, S., Bojarski, C., & Atreya, R. (2017). Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives. Frontiers in Immunology, 8. https://doi.org/10.3389/fimmu.2017.01256
MLA:
Waldner, Maximilian, et al. "Imaging of Mucosal Inflammation: Current Technological Developments, Clinical Implications, and Future Perspectives." Frontiers in Immunology 8 (2017).
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