Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia

Khalil M, Alliger K, Weidinger C, Yerinde C, Wirtz S, Becker C, Engel M (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Frontiers in Immunology Frontiers Research Foundation / Frontiers Media

Book Volume: 9

DOI: 10.3389/fimmu.2018.00174

Abstract

Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel physiology was focusing on its fundamental meaning in sensory neuronal function. Today, it is known that activation of several TRP ion channels in peptidergic neurons does not only result in neuropeptide release and consecutive neurogenic inflammation. Growing evidence demonstrates functional extra-neuronal TRP channel expression in immune and epithelial cells with important implications for mucosal immunology. TRP channels maintain intracellular calcium homeostasis to regulate various functions in the respective cells such as nociception, production and release of inflammatory mediators, phagocytosis, and cell migration. In this review, we provide an overview about TRP-mediated effects in immune and epithelial cells with an emphasis on mucosal immunology of the gut. Crosstalk between neurons, epithelial cells, and immune cells induced by activation of TRP channels orchestrates the immunologic response. Understanding of its molecular mechanisms paves the way to novel clinical approaches for the treatment of various inflammatory disorders including IBD.

Authors with CRIS profile

Mohammad Khalil Lehrstuhl für Physiologie Stefan Wirtz Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology Christoph Becker Professur für Molekulare Gastroenterologie Matthias Engel Department of Medicine 1 – Gastroenterology, Pneumology and Endocrinology

Involved external institutions

Charité - Universitätsmedizin Berlin DE Germany (DE)

How to cite

APA:

Khalil, M., Alliger, K., Weidinger, C., Yerinde, C., Wirtz, S., Becker, C., & Engel, M. (2018). Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia. Frontiers in Immunology, 9. https://dx.doi.org/10.3389/fimmu.2018.00174

MLA:

Khalil, Mohammad, et al. "Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia." Frontiers in Immunology 9 (2018).

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