European Society of Hypertension position paper on renal denervation 2018

Journal article

Publication Details

Author(s): Schmieder R, Mahfoud F, Azizi M, Pathak A, Dimitriadis K, Kroon AA, Ott C, Scalise F, Mancia G, Tsioufis C
Journal: Journal of Hypertension
Publication year: 2018
ISSN: 0263-6352
eISSN: 1473-5598


: This ESH update was deemed necessary with the publication of new results of sham-controlled randomized blinded prospective trials with renal denervation (RDN). Proof of concept studies and first randomized trials (some were sham-controlled) displayed discrepant results about the efficacy of RDN. Three sham-controlled randomized trials of the 2.0 generation yielded now similarity in the average blood pressure decrease following RDN. Reduction of ambulatory blood pressure was approximately 5 to 7 mmHg and of office blood pressure 10 mmHg. Such a decrease in blood pressure by pharmacologic therapy has been found to be associated with lower incidence of cardiovascular events in particular with respect to heart failure and stroke by roughly 25%. Nevertheless, some questions about renal denervation are unanswered. The heterogeneity of the blood pressure-lowering response point to the clinical need to identify predictors for efficacy, and questions on long-term safety could not have been answered due to the short duration of the sham-controlled randomized clinical trials.

FAU Authors / FAU Editors

Ott, Christian PD Dr.
Medizinische Fakultät
Schmieder, Roland Prof. Dr.
Professur für Innere Medizin (Nephrologie)

External institutions with authors

Hippokrateion Hospital
Maastricht University
National and Kapodistrian University of Athens
Policlinico di Monza
Universität des Saarlandes (UdS)
University of Milano-Bicocca / Università degli Studi di Milano-Bicocca, UNIMIB
University of Paris 5 - René Descartes / Université Paris V René Descartes

How to cite

Schmieder, R., Mahfoud, F., Azizi, M., Pathak, A., Dimitriadis, K., Kroon, A.A.,... Tsioufis, C. (2018). European Society of Hypertension position paper on renal denervation 2018. Journal of Hypertension.

Schmieder, Roland, et al. "European Society of Hypertension position paper on renal denervation 2018." Journal of Hypertension (2018).


Last updated on 2019-26-07 at 09:03