Identification of nine new susceptibility loci for endometrial cancer

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann M, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng THT, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox A, Crous-Bous M, Czene K, Day F, Dennis J, Depreeuw J, Doherty JA, Dork T, Dowdy SC, Duerst M, Ekici AB, Fasching P, Fridley BL, Friedenreich CM, Fritschi L, Fung J, Garcia-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison SE, Healey CS, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Le Marchand L, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, Mcevoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir R, Olsson H, Orlow I, Otton G, Palles C, Perry JRB, Peto J, Pooler L, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers PAW, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, Vanden Berg D, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Pharoah PDP, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ
Zeitschrift: Nature Communications
Jahr der Veröffentlichung: 2018
Band: 9
Heftnummer: 1
ISSN: 2041-1723


Abstract

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Beckmann, Matthias Prof. Dr.
Lehrstuhl für Geburtshilfe und Frauenheilkunde
Fasching, Peter PD Dr.
Professur für Translationale Frauenheilkunde und Geburtshilfe
Hein, Alexander PD Dr.
Frauenklinik
Rübner, Matthias PD Dr.
Frauenklinik


Einrichtungen weiterer Autorinnen und Autoren

Alberta Health Services (AHS)
American Cancer Society
Case Western Reserve University
Curtin University
Deutsches Krebsforschungszentrum (DKFZ)
Fred Hutchinson Cancer Research Center
Friedrich-Schiller-Universität Jena
Harvard University
H. Lee Moffitt Cancer Center & Research Institute
John Hunter Hospital
Karolinska Institute
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
London School of Hygiene and Tropical Medicine
Ludwig-Maximilians-Universität (LMU)
Lund University / Lunds universitet
Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie
Mayo Clinic
Medizinische Hochschule Hannover (MHH) / Hannover Medical School
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)
Oslo University Hospital / Oslo Universitetssykehus
QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research)
Robert-Bosch-Krankenhaus
Ruprecht-Karls-Universität Heidelberg
Shanghai Jiao Tong University / 上海交通大学
St George's, University of London (SGUL) / St George's Hospital Medical School
The Institute of Cancer Research (ICR)
The University of Melbourne
Università degli Studi di Torino
University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven
University of Bergen / Universitetet i Bergen
University of Birmingham
University of California Davis (UCDAVIS)
University of Cambridge
University of Hawaii (U.H.)
University of Kansas (KU)
University of Newcastle (UoN)
University of New Mexico
University of Oxford
University of Queensland
University of Sheffield
University of Southern California (USC)
University of Sydney
University of Utah
University of Wisconsin - Madison
Vanderbilt University


Zitierweisen

APA:
O'Mara, T.A., Glubb, D.M., Amant, F., Annibali, D., Ashton, K., Attia, J.,... Thompson, D.J. (2018). Identification of nine new susceptibility loci for endometrial cancer. Nature Communications, 9(1). https://dx.doi.org/10.1038/s41467-018-05427-7

MLA:
O'Mara, Tracy A., et al. "Identification of nine new susceptibility loci for endometrial cancer." Nature Communications 9.1 (2018).

BibTeX: 

Zuletzt aktualisiert 2019-18-07 um 07:26