Identification of nine new susceptibility loci for endometrial cancer

O'Mara TA, Glubb DM, Amant F, Annibali D, Ashton K, Attia J, Auer PL, Beckmann M, Black A, Bolla MK, Brauch H, Brenner H, Brinton L, Buchanan DD, Burwinkel B, Chang-Claude J, Chanock SJ, Chen C, Chen MM, Cheng THT, Clarke CL, Clendenning M, Cook LS, Couch FJ, Cox A, Crous-Bous M, Czene K, Day F, Dennis J, Depreeuw J, Doherty JA, Dork T, Dowdy SC, Duerst M, Ekici AB, Fasching P, Fridley BL, Friedenreich CM, Fritschi L, Fung J, Garcia-Closas M, Gaudet MM, Giles GG, Goode EL, Gorman M, Haiman CA, Hall P, Hankison SE, Healey CS, Hein A, Hillemanns P, Hodgson S, Hoivik EA, Holliday EG, Hopper JL, Hunter DJ, Jones A, Krakstad C, Kristensen VN, Lambrechts D, Le Marchand L, Liang X, Lindblom A, Lissowska J, Long J, Lu L, Magliocco AM, Martin L, Mcevoy M, Meindl A, Michailidou K, Milne RL, Mints M, Montgomery GW, Nassir R, Olsson H, Orlow I, Otton G, Palles C, Perry JRB, Peto J, Pooler L, Prescott J, Proietto T, Rebbeck TR, Risch HA, Rogers PAW, Rübner M, Runnebaum I, Sacerdote C, Sarto GE, Schumacher F, Scott RJ, Setiawan VW, Shah M, Sheng X, Shu XO, Southey MC, Swerdlow AJ, Tham E, Trovik J, Turman C, Tyrer JP, Vachon C, Vanden Berg D, Vanderstichele A, Wang Z, Webb PM, Wentzensen N, Werner HMJ, Winham SJ, Wolk A, Xia L, Xiang YB, Yang HP, Yu H, Zheng W, Pharoah PDP, Dunning AM, Kraft P, De Vivo I, Tomlinson I, Easton DF, Spurdle AB, Thompson DJ (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Book Volume: 9

Journal Issue: 1

DOI: 10.1038/s41467-018-05427-7

Abstract

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes; risk alleles at two of these loci associate with decreased expression of genes, which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

Authors with CRIS profile

Involved external institutions

QIMR Berghofer Medical Research Institute (früher: the Queensland Institute of Medical Research) Australia (AU) Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven Belgium (BE) John Hunter Hospital Australia (AU) National Cancer Institute (NCI) United States (USA) (US) University of Cambridge United Kingdom (GB) Robert-Bosch-Krankenhaus Germany (DE) Deutsches Krebsforschungszentrum (DKFZ) Germany (DE) The University of Melbourne Australia (AU) Ruprecht-Karls-Universität Heidelberg Germany (DE) Fred Hutchinson Cancer Research Center Canada (CA) Harvard University United States (USA) (US) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Mayo Clinic United States (USA) (US) London School of Hygiene and Tropical Medicine United Kingdom (GB) University of Southern California (USC) United States (USA) (US) University of Newcastle (UoN) Australia (AU) Yale University United States (USA) (US) Karolinska Institute Sweden (SE) University of Hawaii (U.H.) United States (USA) (US) Vanderbilt University United States (USA) (US) University of Oxford United Kingdom (GB) University of Sydney (USYD) Australia (AU) University of New Mexico (UNM) / Universidad de Nuevo México United States (USA) (US) University of Sheffield United Kingdom (GB) University of Utah United States (USA) (US) Friedrich-Schiller-Universität Jena Germany (DE) University of Kansas (KU) United States (USA) (US) Alberta Health Services (AHS) Canada (CA) University of Queensland Australia (AU) American Cancer Society United States (USA) (US) St George's, University of London (SGUL) / St George's Hospital Medical School United Kingdom (GB) University of Bergen / Universitetet i Bergen Norway (NO) Oslo University Hospital / Oslo Universitetssykehus Rikshospitalet Norway (NO) Memorial Sloan Kettering Cancer Center United States (USA) (US) Maria Skłodowska-Curie Institute of Oncology / Centrum Onkologii–Instytut im. Marii Skłodowskiej-Curie w Warszawie Poland (PL) H. Lee Moffitt Cancer Center & Research Institute United States (USA) (US) University of Birmingham United Kingdom (GB) Ludwig-Maximilians-Universität (LMU) Germany (DE) University of California Davis (UCDAVIS) United States (USA) (US) Lund University / Lunds universitet Sweden (SE) University of Turin / Università degli Studi di Torino (UNITO) Italy (IT) University of Wisconsin - Madison United States (USA) (US) Curtin University Australia (AU) Case Western Reserve University United States (USA) (US) The Institute of Cancer Research (ICR) United Kingdom (GB) University Hospital Leuven (UZ) / Universitaire ziekenhuizen Leuven Belgium (BE) Shanghai Jiao Tong University / 上海交通大学 China (CN)

How to cite

APA:

O'Mara, T.A., Glubb, D.M., Amant, F., Annibali, D., Ashton, K., Attia, J.,... Thompson, D.J. (2018). Identification of nine new susceptibility loci for endometrial cancer. Nature Communications, 9(1). https://dx.doi.org/10.1038/s41467-018-05427-7

MLA:

O'Mara, Tracy A., et al. "Identification of nine new susceptibility loci for endometrial cancer." Nature Communications 9.1 (2018).

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