Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Lehmann HI, Graeff C, Simoniello P, Constantinescu A, Takami M, Lugenbiel P, Richter D, Eichhorn A, Prall M, Kaderka R, Fiedler F, Helmbrecht S, Fournier C, Erbeldinger N, Rahm AK, Rivinius R, Thomas D, Katus HA, Johnson SB, Parker KD, Debus J, Asirvatham SJ, Bert C, Durante M, Packer DL
Zeitschrift: Scientific Reports
Jahr der Veröffentlichung: 2016
Band: 6
ISSN: 2045-2322


Abstract

High-energy ion beams are successfully used in cancer therapy and precisely deliver high doses of ionizing radiation to small deep-seated target volumes. A similar noninvasive treatment modality for cardiac arrhythmias was tested here. This study used high-energy carbon ions for ablation of cardiac tissue in pigs. Doses of 25, 40, and 55 Gy were applied in forced-breath-hold to the atrioventricular junction, left atrial pulmonary vein junction, and freewall left ventricle of intact animals. Procedural success was tracked by (1.) in-beam positron-emission tomography (PET) imaging; (2.) intracardiac voltage mapping with visible lesion on ultrasound; (3.) lesion outcomes in pathohistolgy. High doses (40-55 Gy) caused slowing and interruption of cardiac impulse propagation. Target fibrosis was the main mediator of the ablation effect. In irradiated tissue, apoptosis was present after 3, but not 6 months. Our study shows feasibility to use high-energy ion beams for creation of cardiac lesions that chronically interrupt cardiac conduction.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Bert, Christoph Prof. Dr. rer. nat.
Professur für Med. Strahlenphysik


Einrichtungen weiterer Autorinnen und Autoren

GSI Helmholtzzentrum für Schwerionenforschung GmbH
Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
Mayo Clinic
Ruprecht-Karls-Universität Heidelberg
Universitätsklinikum Heidelberg


Zitierweisen

APA:
Lehmann, H.I., Graeff, C., Simoniello, P., Constantinescu, A., Takami, M., Lugenbiel, P.,... Packer, D.L. (2016). Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams. Scientific Reports, 6. https://dx.doi.org/10.1038/srep38895

MLA:
Lehmann, H. Immo, et al. "Feasibility Study on Cardiac Arrhythmia Ablation Using High-Energy Heavy Ion Beams." Scientific Reports 6 (2016).

BibTeX: 

Zuletzt aktualisiert 2019-28-02 um 06:12