Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow

Journal article


Publication Details

Author(s): Haberland K, Ackermann JA, Ipseiz N, Culemann S, Pracht K, Englbrecht M, Jäck HM, Schett G, Schuh W, Krönke G
Journal: European Journal of Immunology
Publication year: 2018
Volume: 48
Journal issue: 5
Pages range: 822-828
ISSN: 0014-2980


Abstract

Eosinophils were reported to serve as an essential component of the plasma cell niche within the bone marrow. As the potential contribution of eosinophils to humoral immunity has remained incompletely understood, we aimed to further characterize their role during antibody responses and to additionally investigate their role in autoimmune disease. Contrary to our expectations and the currently prevailing paradigm, we found that eosinophils are fully dispensable for the survival of murine bone marrow plasma cells and accordingly do not contribute to antibody production and autoantibody-mediated disease. Littermate wild type and eosinophil-deficient ΔdblGATA-1 animals showed similar numbers and frequencies of plasma cells and did not differ in steady state levels of immunoglobulins or their ability to raise antigen-specific antibody responses. Eosinophils were likewise dispensable for autoantibody production or autoantibody-induced disease in a mouse model of systemic lupus erythematosus. Our findings thus argue against a role of eosinophils during the maintenance of the plasma cell pool and challenge the hitherto postulated concept of an eosinophil-sustained bone marrow niche.


FAU Authors / FAU Editors

Englbrecht, Matthias
Lehrstuhl für Innere Medizin III
Haberland, Konrad
Professur für Translationale Immunologie
Jäck, Hans-Martin Prof. Dr.
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3
Krönke, Gerhard Prof. Dr. med.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Pracht, Katharina Dr. rer. nat.
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III
Schuh, Wolfgang Dr. rer. nat.
Molekular-Immunologische Abteilung in der Medizinischen Klinik 3


How to cite

APA:
Haberland, K., Ackermann, J.A., Ipseiz, N., Culemann, S., Pracht, K., Englbrecht, M.,... Krönke, G. (2018). Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow. European Journal of Immunology, 48(5), 822-828. https://dx.doi.org/10.1002/eji.201747227

MLA:
Haberland, Konrad, et al. "Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow." European Journal of Immunology 48.5 (2018): 822-828.

BibTeX: 

Last updated on 2019-05-01 at 18:10

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