Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

Journal article


Publication Details

Author(s): Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter-Zaiss K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss M
Journal: Cell Reports
Publication year: 2018
Volume: 24
Journal issue: 1
Pages range: 169-180
ISSN: 2211-1247


Abstract

Group 2 innate lymphoid cells (ILC2s) were detected in the peripheral blood and the joints of rheumatoid arthritis (RA) patients, serum-induced arthritis (SIA), and collagen-induced arthritis (CIA) using flow cytometry. Circulating ILC2s were significantly increased in RA patients compared with healthy controls and inversely correlated with disease activity. Induction of arthritis in mice led to a fast increase in ILC2 number. To elucidate the role of ILC2 in arthritis, loss- and gain-of-function mouse models for ILC2 were subjected to arthritis. Reduction of ILC2 numbers in RORαcre/GATA3fl/fl and Tie2cre/RORαfl/fl mice significantly exacerbated arthritis. Increasing ILC2 numbers in mice by IL-25/IL-33 mini-circles or IL-2/IL-2 antibody complex and the adoptive transfer of wild-type (WT) ILC2s significantly attenuated arthritis by affecting the initiation phase. In addition, adoptive transfer of IL-4/13-competent WT but not IL-4/13-/- ILC2s and decreased cytokine secretion by macrophages. These data show that ILC2s have immune-regulatory functions in arthritis.


FAU Authors / FAU Editors

Andreev, Darja
Medizinische Klinik 3 - Rheumatologie und Immunologie
Bozec, Aline Prof. Dr.
Juniorprofessur für Osteoimmunologie
Krönke, Gerhard Prof. Dr. med.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Primbs, Tatjana
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
Sarter-Zaiss, Kerstin Dr. rer. nat.
Medizinische Klinik 3 - Rheumatologie und Immunologie
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III
Wirtz, Stefan PD Dr.
Medizinische Klinik 1 - Gastroenterologie, Pneumologie und Endokrinologie
Zaiss, Mario PD Dr.
Medizinische Klinik 3 - Rheumatologie und Immunologie


External institutions
Universitätsklinikum Jena
University of Amsterdam


How to cite

APA:
Omata, Y., Frech, M., Primbs, T., Lucas, S., Andreev, D., Scholtysek, C.,... Zaiss, M. (2018). Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Reports, 24(1), 169-180. https://dx.doi.org/10.1016/j.celrep.2018.06.005

MLA:
Omata, Yasunori, et al. "Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice." Cell Reports 24.1 (2018): 169-180.

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Last updated on 2019-11-04 at 13:32