Going single but not solo with podocytes: potentials, limitations, and pitfalls of single-cell analysis

Schiffer M (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Kidney International Nature Publishing Group: Open Access Hybrid Model Option A

Book Volume: 92

Pages Range: 1038-1041

Journal Issue: 5

DOI: 10.1016/j.kint.2017.05.033

Abstract

Single-cell RNA-sequence (RNA-seq) is a widely used tool to study biological questions in single cells. The discussed study identified 92 genes being predominantly expressed in podocytes based on a 5-fold higher expression compared with endothelial and mesangial cells. In addition to technical pitfalls, the question that is discussed in this commentary is whether results of a single-cell RNAseq study are able to deliver expression data that truly characterize a podocyte.

Authors with CRIS profile

Mario Schiffer

Additional Organisation(s)

Lehrstuhl für Innere Medizin IV

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Schiffer, M. (2017). Going single but not solo with podocytes: potentials, limitations, and pitfalls of single-cell analysis. Kidney International, 92(5), 1038-1041. https://doi.org/10.1016/j.kint.2017.05.033

MLA:

Schiffer, Mario. "Going single but not solo with podocytes: potentials, limitations, and pitfalls of single-cell analysis." Kidney International 92.5 (2017): 1038-1041.

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