Quantitative evaluation of nanoparticle classification by size-exclusion chromatography

Beitrag in einer Fachzeitschrift
(Originalarbeit)


Details zur Publikation

Autorinnen und Autoren: Süß S, Metzger C, Damm C, Segets D, Peukert W
Zeitschrift: Powder Technology
Verlag: Elsevier B.V.
Jahr der Veröffentlichung: 2018
Band: 339
Seitenbereich: 264-272
ISSN: 0032-5910
eISSN: 1873-328X


Abstract

Although few attempts for classification of nanoparticles (NPs) in labscale do exist, the transfer to industrial applications is still challenging. One promising separation method, which is already established for biological molecules, is chromatography. Herein, we study the classification of differently sized gold NPs (AuNPs) by size-exclusion chromatography (SEC). First, we investigated the interactions of AuNPs with potential stationary phases in order to identify a suitable material for the chromatographic process where irreversible NP adhesion is excluded. Then, we demonstrate the high reproducibility of our SEC experiments by multiple sample injections that lead to constant peak areas. In particular, we show the size-dependent elution behavior of AuNP mixtures resulting in bimodal elution peaks, where size separation was confirmed by inline measured UV/Vis spectra. Finally, NP classification results by using a fraction collector are characterized by retention time, mass balances and size-dependent separation efficiencies. The adjustment of the particle size distributions (PSDs) is demonstrated by changing the switching time of the fraction collector. Our study evidences the high potential of SEC for preparative and continuous separation of NPs.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Damm, Cornelia Dr.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Peukert, Wolfgang Prof. Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Segets, Doris Dr.-Ing.
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik
Süß, Sebastian
Lehrstuhl für Feststoff- und Grenzflächenverfahrenstechnik


Zusätzliche Organisationseinheit(en)
Exzellenz-Cluster Engineering of Advanced Materials


Einrichtungen weiterer Autorinnen und Autoren

Technische Universität München (TUM)


Forschungsbereiche

A1 Functional Particle Systems
Exzellenz-Cluster Engineering of Advanced Materials


Zitierweisen

APA:
Süß, S., Metzger, C., Damm, C., Segets, D., & Peukert, W. (2018). Quantitative evaluation of nanoparticle classification by size-exclusion chromatography. Powder Technology, 339, 264-272. https://dx.doi.org/10.1016/j.powtec.2018.08.008

MLA:
Süß, Sebastian, et al. "Quantitative evaluation of nanoparticle classification by size-exclusion chromatography." Powder Technology 339 (2018): 264-272.

BibTeX: 

Zuletzt aktualisiert 2019-12-07 um 13:20