Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study

Journal article


Publication Details

Author(s): Kerker F, Adler W, Brunner K, Moest T, Wurm M, Nkenke E, Neukam FW, von Wilmowsky C
Journal: Clinical Oral Investigations
Publication year: 2018
Volume: 22
Journal issue: 4
Pages range: 1625-1630
ISSN: 1432-6981


Abstract

OBJECTIVES: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins.
MATERIALS AND METHODS: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]).
RESULTS: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02).
CONCLUSIONS: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin.
CLINICAL RELEVANCE: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.


FAU Authors / FAU Editors

Adler, Werner PD Dr.
Lehrstuhl für Biometrie und Epidemiologie
Kerker, Florian
Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie
Neukam, Friedrich Wilhelm Prof. Dr. Dr.
Lehrstuhl für Zahnmedizin, insbesondere Mund-, Kiefer-, und Gesichtschirurgie
von Wilmowsky, Cornelius PD Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik
Wurm, Matthias Dr.
Mund-, Kiefer- und Gesichtschirurgische Klinik


External institutions
Medizinische Universität Wien


How to cite

APA:
Kerker, F., Adler, W., Brunner, K., Moest, T., Wurm, M., Nkenke, E.,... von Wilmowsky, C. (2018). Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study. Clinical Oral Investigations, 22(4), 1625-1630. https://dx.doi.org/10.1007/s00784-018-2424-z

MLA:
Kerker, Florian, et al. "Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin-a retrospective study." Clinical Oral Investigations 22.4 (2018): 1625-1630.

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Last updated on 2019-05-01 at 16:10