Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP)

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Offenmüller S, Leiter U, Bernbeck B, Garbe C, Eigentler T, Borkhardt A, Classen CF, Corbacioglu S, Dirksen U, Ebetsberger-Dachs G, Heinzerling L, Jorch N, Kuhlen M, Lawlor J, Niggli F, Streiter M, Schneider DT, Brecht I
Zeitschrift: Klinische Pädiatrie
Jahr der Veröffentlichung: 2017
Band: 229
Heftnummer: 6
Seitenbereich: 322-328
ISSN: 0300-8630
eISSN: 1439-3824


Abstract

Background Malignant melanoma (MM) is a common malignancy in adults while it is rare in children. Thus, information on clinical behavior of pediatric MM is incomplete. Patients The German Pediatric Rare Tumor Registry (STEP) presents a prospective analysis of 60 childhood MM cases diagnosed between June 2006 and December 2014. Method Patients' ages ranged between 0 and 17 years at initial diagnosis (median age 9.6 years). Information on patient's and tumor characteristics was obtained by standardized documentation. Three-year overall survival (OS) and event-free survival (EFS) were estimated by the Kaplan-Meier test. Results Follow-up ranged from 0 to 116 months with a median of 36.5 months, however, univariate analysis was performed for 46 cases with a follow-up > 3 months, only. Cases with spitzoid histotype (40%) did not show a significantly different outcome compared to cases with non-spitzoid MM. Breslow thickness ≤ 2.00 mm was identified in 30% of the cases and 18% were Clark level I to III. Adjuvant therapy was used in 45% of cases. OS at 3 years was 100%, EFS 95.2%. Conclusion We present a series of cases with a high number of spitzoid malignant melanoma and advanced pediatric melanoma, but surprisingly good overall survival rates. Spitzoid and non-spitzoid MM do not differ in clinical behavior and survival.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Heinzerling, Lucie Prof. Dr.
Hautklinik
Diez, Sonja Dr. med.
Kinder- und Jugendklinik


Einrichtungen weiterer Autorinnen und Autoren

Evangelisches Krankenhaus Bielefeld
Kepler Universitätsklinikum (KUK)
Klinikum Dortmund
SLK-Kliniken Heilbronn GmbH
Universität Regensburg
Universitäts-Kinderspital Zürich
Universitätsklinikum Düsseldorf
Universitätsklinikum Essen
Universitätsklinikum Magdeburg A.ö.R.
Universitätsklinikum Tübingen
Universitätsmedizin Rostock


Zitierweisen

APA:
Offenmüller, S., Leiter, U., Bernbeck, B., Garbe, C., Eigentler, T., Borkhardt, A.,... Brecht, I. (2017). Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP). Klinische Pädiatrie, 229(6), 322-328. https://dx.doi.org/10.1055/s-0043-118662

MLA:
Offenmüller, Sonja, et al. "Clinical characteristics and outcome of 60 pediatric patients with malignant melanoma registered with the German Pediatric Rare Tumor Registry (STEP)." Klinische Pädiatrie 229.6 (2017): 322-328.

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Zuletzt aktualisiert 2019-01-08 um 10:38