Reversal of aging and lifespan elongation. Current biomedical key publications and the implications for geriatrics
Bollheimer C, Volkert D, Bertsch T, Sieber C, Buettner R (2013)
Publication Status: Published
Publication Type: Journal article
Publication year: 2013
Journal
Publisher: SPRINGER HEIDELBERG
Book Volume: 46
Pages Range: 563-568
Journal Issue: 6
DOI: 10.1007/s00391-012-0415-2
Abstract
Biological aging means a time-dependent accumulation of changes to which a living organism is being exposed during its lifetime. Biological aging normally concurs with chronological aging the time frame of which is set by an upper limit, the lifespan (in humans approximately 120 years). New findings in experimental biogerontology are challenging both the dogma of irreversibility of biological aging and the preset species-specific limitations of life. The present overview first explains the general principle of rejuvenation and reversal of biological aging with paradigms from stem cell research. Secondly, recent key publications on artificial telomerase elongation and (alleged) lifespan enhancement by sirtuins and resveratrol will be discussed with an emphasis on the implications for (future) geriatric medicine.
Authors with CRIS profile
Cornelius Bollheimer
Professur für Innere Medizin - Geriatrie
Dorothee Volkert
Professur für Klinische Ernährung im Alter
Cornel Sieber
Lehrstuhl für Innere Medizin (Geriatrie)
Involved external institutions
Germany (DE)How to cite
APA:
Bollheimer, C., Volkert, D., Bertsch, T., Sieber, C., & Buettner, R. (2013). Reversal of aging and lifespan elongation. Current biomedical key publications and the implications for geriatrics. Zeitschrift für Gerontologie und Geriatrie, 46(6), 563-568. https://dx.doi.org/10.1007/s00391-012-0415-2
MLA:
Bollheimer, Cornelius, et al. "Reversal of aging and lifespan elongation. Current biomedical key publications and the implications for geriatrics." Zeitschrift für Gerontologie und Geriatrie 46.6 (2013): 563-568.
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