Promoting access to innovation for frail old persons

Journal article

Publication Details

Author(s): Berrut G, Andrieu S, De Carvalho IA, Baeyens JP, Bergman H, Cassim B, Cerreta F, Cesari M, Cha HB, Chen LK, Cherubini A, Chou MY, Cruz-Jentoft AJ, De Decker L, Du P, Forette B, Forette F, Franco A, Guimaraes R, Gutierrez-Robledo LM, Jauregui J, Khavinson V, Lee WJ, Peng LN, Perret-Guillaume C, Petrovic M, Retornaz F, Rockwood K, Rodriguez-Manas L, Sieber C, Spatharakis G, Theou O, Topinkova E, Vellas B, Benetos A
Journal: The journal of nutrition, health & aging
Publication year: 2013
Volume: 17
Journal issue: 8
Pages range: 688-693
ISSN: 1279-7707
eISSN: 1760-4788


Frailty tends to be considered as a major risk for adverse outcomes in older persons, but some important aspects remain matter of debate.The purpose of this paper is to present expert's positions on the main aspects of the frailty syndrome in the older persons.Workshop organized by International Association of Gerontology and Geriatrics (IAGG), World Health Organization (WHO) and Soci,t, Fran double dagger aise de G,riatrie et de G,rontologie (SFGG).Frailty is widely recognized as an important risk factor for adverse health outcomes in older persons. This can be of particular value in evaluating non-disabled older persons with chronic diseases but today no operational definition has been established. Nutritional status, mobility, activity, strength, endurance, cognition, and mood have been proposed as markers of frailty. Another approach calculates a multidimensional score ranging from "very fit" to "severely frail," but it is difficult to apply into the medical practice. Frailty appears to be secondary to multiple conditions using multiple pathways leading to a vulnerability to a stressor. Biological (inflammation, loss of hormones), clinical (sarcopenia, osteoporosis etc.), as well as social factors (isolation, financial situation) are involved in the vulnerability process. In clinical practice, detection of frailty is of major interest in oncology because of the high prevalence of cancer in older persons and the bad tolerance of the drug therapies. Presence of frailty should also be taken into account in the definition of the cardiovascular risks in the older population. The experts of the workshop have listed the points reached an agreement and those must to be a priority for improving understanding and use of frailty syndrome in practice.Frailty in older adults is a syndrome corresponding to a vulnerability to a stressor. Diagnostic tools have been developed but none can integrate at the same time the large spectrum of factors and the simplicity asked by the clinical practice. An agreement with an international common definition is necessary to develop screening and to reduce the morbidity in older persons.

FAU Authors / FAU Editors

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)

External institutions with authors

Az Damiaan
Centre Gérontologique Départemental de Marseille
Centre Hospitalier Universitaire (CHU) de Toulouse
Chu De Nancy - Hôpitaux De Brabois
Dalhousie University
European Medicines Agency
Hallym University
Hôpital l'Archet (CHU de Nice)
Hôpital Sainte-Périne / Sainte-Perine Hospital
Hospital Italiano de Buenos Aires
Hospital Universitario de Getafe
Hospital Universitario Ramón y Cajal
Instituto Nacional de Geriatría
Istituto Nazionale di Riposo e Cura per Anziani (IRCCS INRCA)
Kaohsiung Veterans General Hospital
McGill University
Nantes University Hospital / Centre hospitalier universitaire de Nantes (CHU)
National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM)
Renmin University of China
St. Petersburg Institute of Bioregulation and Gerontology
Taipei Veterans General Hospital / 台北榮民總醫院
University Hospital Ghent
Univerzita Karlova v Praze / Charles University in Prague
World Health Organization

How to cite

Berrut, G., Andrieu, S., De Carvalho, I.A., Baeyens, J.P., Bergman, H., Cassim, B.,... Benetos, A. (2013). Promoting access to innovation for frail old persons. The journal of nutrition, health & aging, 17(8), 688-693.

Berrut, G., et al. "Promoting access to innovation for frail old persons." The journal of nutrition, health & aging 17.8 (2013): 688-693.


Last updated on 2018-15-11 at 08:23