Frailty and sarcopenia: definitions and outcome parameters

Beitrag in einer Fachzeitschrift

Details zur Publikation

Autorinnen und Autoren: Cooper C, Dere W, Evans W, Kanis JA, Rizzoli R, Sayer AA, Sieber C, Kaufman JM, Van Kan GA, Boonen S, Adachi J, Mitlak B, Tsouderos Y, Rolland Y, Reginster JYL
Zeitschrift: Osteoporosis international
Jahr der Veröffentlichung: 2012
Band: 23
Heftnummer: 7
Seitenbereich: 1839-1848
ISSN: 0937-941X
eISSN: 1433-2965


An operational definition of musculoskeletal decline in older people is needed to allow development of interventions for prevention or treatment, as was developed for the treatment of osteoporosis. Frailty and sarcopenia are linked, but distinct, correlates of musculoskeletal aging that have many causes, including age-related changes in body composition, inflammation, and hormonal imbalance. With the emergence of a number of exciting candidate therapies to retard the loss of muscle mass with aging, the derivation of a consensual definition of sarcopenia and physical frailty becomes an urgent priority. Although several consensual definitions have been proposed, these require clinical validation. An operational definition, which might provide a threshold for treatment/trial inclusion, should incorporate a loss of muscle mass as well as evidence of a decrease in muscle strength and/or physical activity. Evidence is required for a link between improvements in the measures of muscle strength and/or physical activity and clinical outcomes to allow development of interventions to improve clinical outcomes in frail older patients.

FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Sieber, Cornel Prof. Dr.
Lehrstuhl für Innere Medizin (Geriatrie)

Einrichtungen weiterer Autorinnen und Autoren

Amgen Ltd
Centre Hospitalier Universitaire (CHU) de Toulouse
Eli Lilly and Company
Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG)
GlaxoSmithKline plc. (GSK)
Katholieke Universiteit Leuven (KUL) / Catholic University of Leuven
McMaster University
University Hospital Ghent
University of Liège (ULg) / Université de Liège
University of Sheffield
University of Southampton


Cooper, C., Dere, W., Evans, W., Kanis, J.A., Rizzoli, R., Sayer, A.A.,... Reginster, J.-Y.L. (2012). Frailty and sarcopenia: definitions and outcome parameters. Osteoporosis international, 23(7), 1839-1848.

Cooper, Cyrus, et al. "Frailty and sarcopenia: definitions and outcome parameters." Osteoporosis international 23.7 (2012): 1839-1848.


Zuletzt aktualisiert 2018-14-11 um 03:08