Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo

Seidel K, Balakrishnan A, Alexiou C, Janko C, Komoll RM, Wang LL, Kirschning A, Ott M (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Chemistry - A European Journal Wiley-VCH Verlag

Book Volume: 23

Pages Range: 12326-12337

Journal Issue: 50

DOI: 10.1002/chem.201701491

Abstract

Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour-selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis. Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model. Biocompatibility studies for these magnetic-nanoparticle/ansamitocin conjugates complement this work.

Authors with CRIS profile

Christoph Alexiou Professur für Nanomedizin Christina Janko Department of Otorhinolaryngology – Head and Neck Surgery

Involved external institutions

Gottfried Wilhelm Leibniz Universität Hannover DE Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE)

How to cite

APA:

Seidel, K., Balakrishnan, A., Alexiou, C., Janko, C., Komoll, R.-M., Wang, L.-L.,... Ott, M. (2017). Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo. Chemistry - A European Journal, 23(50), 12326-12337. https://dx.doi.org/10.1002/chem.201701491

MLA:

Seidel, Katja, et al. "Synthesis of Magnetic-Nanoparticle/Ansamitocin Conjugates-Inductive Heating Leads to Decreased Cell Proliferation In Vitro and Attenuation Of Tumour Growth In Vivo." Chemistry - A European Journal 23.50 (2017): 12326-12337.

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