Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles

Beitrag in einer Fachzeitschrift


Details zur Publikation

Autorinnen und Autoren: Zaloga J, Feoktystov A, Garamus VM, Karawacka W, Ioffe A, Brueckel T, Tietze R, Alexiou C, Lyer S
Zeitschrift: Colloids and Surfaces B-Biointerfaces
Jahr der Veröffentlichung: 2018
Band: 161
Seitenbereich: 18-26
ISSN: 0927-7765


Abstract

A rational use of superparamagnetic iron oxide nanoparticles (SPIONs) in drug delivery, diagnostics, and other biomedical applications requires deep understanding of the molecular drug adsorption/desorption mechanisms for proper design of new pharmaceutical formulations. The adsorption and desorption of the cytostatic Mitoxantrone (MTO) to lauric acid-albumin hybrid coated particles SPIONs (SEONLA-HSA) was studied by Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), surface titration, release experiments and small-angle neutron and X-ray scattering. Such MTO-loaded nanoparticles have shown very promising results in in vivo animal models before, while the exact binding mechanism of the drug was unknown. SEONLA-HSAformulations have shown better stability under drug loading in comparison with uncoated nanoparticle and sustainable drug release to compare with protein solution. Adsorption of MTO to SEONLA-HSAleads to decreasing of absolute value of zeta potential and repulsive interaction among particles, which points to the location of separate molecules of MTO on the outer surface of LA-HSA shell.


FAU-Autorinnen und Autoren / FAU-Herausgeberinnen und Herausgeber

Alexiou, Christoph Prof. Dr.
Tietze, Rainer Dr. rer. nat.
Professur für Nanomedizin
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Lyer, Stefan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie
Zaloga, Jan Dr. rer. nat.
Hals-Nasen-Ohren-Klinik - Kopf- und Halschirurgie


Einrichtungen weiterer Autorinnen und Autoren

Forschungszentrum Jülich GmbH (FZJ)
Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH (HZG)


Zitierweisen

APA:
Zaloga, J., Feoktystov, A., Garamus, V.M., Karawacka, W., Ioffe, A., Brueckel, T.,... Lyer, S. (2018). Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles. Colloids and Surfaces B-Biointerfaces, 161, 18-26. https://dx.doi.org/10.1016/j.colsurfb.2017.09.057

MLA:
Zaloga, Jan, et al. "Studies on the adsorption and desorption of mitoxantrone to lauric acid/albumin coated iron oxide nanoparticles." Colloids and Surfaces B-Biointerfaces 161 (2018): 18-26.

BibTeX: 

Zuletzt aktualisiert 2018-19-11 um 09:53