Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG

Journal article


Publication Details

Author(s): Knopf J, Magorivska I, Maier JN, Spitzer P, Bilyy R, Biermann M, Hychka K, Bondt A, Wuhrer M, Toes REM, Schett G, Herrmann M, Munoz LE
Journal: Journal of Neuroimmunology
Publication year: 2018
Volume: 320
Pages range: 19-24
ISSN: 0165-5728


Abstract

Immunoglobulin G (IgG) harbors a conserved N-glycosylation site which is important for its effector functions. Changes in glycosylation of IgG occur in many autoimmune diseases but also in physiological conditions. Therefore, the glycosylation pattern of serum IgG is well characterized. However, limited data is available on the glycosylation pattern of IgG in cerebrospinal fluid (CSF) compared to serum. Here, we report significantly reduced levels of bisected glycans in CSF IgG. Galactosylation and sialylation of IgG4 also differed significantly. Therefore, we propose a common mechanism mediating glycosylation changes of IgG at the transition from serum to CSF in steady state conditions.


FAU Authors / FAU Editors

Biermann, Mona
Lehrstuhl für Biochemie und Molekulare Medizin
Herrmann, Martin Prof. Dr.
Knopf, Jasmin
Medizinische Klinik 3 - Rheumatologie und Immunologie
Medizinische Klinik 3 - Rheumatologie und Immunologie
Maier, Jan-Niklas Dr. med.
Medizinische Fakultät
Schett, Georg Prof. Dr. med.
Lehrstuhl für Innere Medizin III
Spitzer, Philipp PD Dr.
Psychiatrische und Psychotherapeutische Klinik


External institutions with authors

Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького
Leiden University


How to cite

APA:
Knopf, J., Magorivska, I., Maier, J.-N., Spitzer, P., Bilyy, R., Biermann, M.,... Munoz, L.E. (2018). Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG. Journal of Neuroimmunology, 320, 19-24. https://dx.doi.org/10.1016/j.jneuroim.2018.04.010

MLA:
Knopf, Jasmin, et al. "Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG." Journal of Neuroimmunology 320 (2018): 19-24.

BibTeX: 

Last updated on 2018-11-10 at 14:08