Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG

Knopf J, Magorivska I, Maier JN, Spitzer P, Bilyy R, Biermann M, Hychka K, Bondt A, Wuhrer M, Toes REM, Schett G, Herrmann M, Munoz LE (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Journal of Neuroimmunology Elsevier

Book Volume: 320

Pages Range: 19-24

DOI: 10.1016/j.jneuroim.2018.04.010

Abstract

Immunoglobulin G (IgG) harbors a conserved N-glycosylation site which is important for its effector functions. Changes in glycosylation of IgG occur in many autoimmune diseases but also in physiological conditions. Therefore, the glycosylation pattern of serum IgG is well characterized. However, limited data is available on the glycosylation pattern of IgG in cerebrospinal fluid (CSF) compared to serum. Here, we report significantly reduced levels of bisected glycans in CSF IgG. Galactosylation and sialylation of IgG4 also differed significantly. Therefore, we propose a common mechanism mediating glycosylation changes of IgG at the transition from serum to CSF in steady state conditions.

Authors with CRIS profile

Jasmin Knopf Department of Medicine 3 – Rheumatology and Immunology Jan-Niklas Maier Medizinische Fakultät Philipp Spitzer Department of Psychiatry and Psychotherapy Mona Biermann Lehrstuhl für Biochemie und Molekulare Medizin Georg Schett Lehrstuhl für Innere Medizin III Martin Herrmann Department of Medicine 3 – Rheumatology and Immunology Luis Munoz Becerra Department of Medicine 3 – Rheumatology and Immunology

Involved external institutions

Leiden University NL Netherlands (NL) Danylo Halytsky Lviv National Medical University / Львiвський Національний Медичний Унiверситет iм. Данила Галицького UA Ukraine (UA)

How to cite

APA:

Knopf, J., Magorivska, I., Maier, J.-N., Spitzer, P., Bilyy, R., Biermann, M.,... Munoz, L.E. (2018). Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG. Journal of Neuroimmunology, 320, 19-24. https://dx.doi.org/10.1016/j.jneuroim.2018.04.010

MLA:

Knopf, Jasmin, et al. "Low amounts of bisecting glycans characterize cerebrospinal fluid-borne IgG." Journal of Neuroimmunology 320 (2018): 19-24.

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