Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb
Schenk H, Müller-Deile J, Schmitt R, Braesen JH, Haller H, Schiffer M (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 32
Pages Range: 444-452
Journal Issue: 6
DOI: 10.1002/jca.21538
Abstract
Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied. Efficiency of total plasma exchange to remove suPAR was determined. CytoSorb hemoadsorption caused a 27.33% reduction of the suPAR level in a single treatment, whereas total plasma exchange showed a suPAR level reduction of 25.12% (n = 3; 95% confidence interval, 0.2777-0.8090; P < 0.01), which may indicate therapeutic potential in the treatment of primary FSGS and its recurrence in a kidney transplant.
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Germany (DE)How to cite
APA:
Schenk, H., Müller-Deile, J., Schmitt, R., Braesen, J.H., Haller, H., & Schiffer, M. (2017). Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb. Journal of Clinical Apheresis, 32(6), 444-452. https://doi.org/10.1002/jca.21538
MLA:
Schenk, Heiko, et al. "Removal of focal segmental glomerulosclerosis (FSGS) factor suPAR using CytoSorb." Journal of Clinical Apheresis 32.6 (2017): 444-452.
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