Neural basis of reward anticipation and its genetic determinants

Journal article

Publication Details

Author(s): Jia T, Macare C, Desrivieres S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Buechel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, Müller CP, Feng J, Rothenfluh A, Flor H, Schumann G
Journal: Proceedings of the National Academy of Sciences
Publication year: 2016
Volume: 113
Journal issue: 14
Pages range: 3879-84
ISSN: 0027-8424
eISSN: 1091-6490


Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

FAU Authors / FAU Editors

Müller, Christian P. Prof. Dr.
Professur für Suchtmedizin

External institutions
French Alternative Energies and Atomic Energy Commission (CEA)
Fudan University / 复旦大学
King’s College London
McGill University
Physikalisch-Technische Bundesanstalt (PTB)
Ruprecht-Karls-Universität Heidelberg
Technische Universität Dresden
Trinity College Dublin
Universitätsklinikum Hamburg-Eppendorf (UKE)
University of California, Berkeley
University of Cambridge
University of Nottingham
University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud
University of Texas Southwestern Medical Center (UT Southwestern)
University of Toronto
University of Vermont

How to cite

Jia, T., Macare, C., Desrivieres, S., Gonzalez, D.A., Tao, C., Ji, X.,... Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences, 113(14), 3879-84.

Jia, Tianye, et al. "Neural basis of reward anticipation and its genetic determinants." Proceedings of the National Academy of Sciences 113.14 (2016): 3879-84.


Last updated on 2018-14-11 at 08:08