Neural basis of reward anticipation and its genetic determinants

Jia T, Macare C, Desrivieres S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Buechel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, Müller CP, Feng J, Rothenfluh A, Flor H, Schumann G (2016)

Publication Type: Journal article

Publication year: 2016

Journal

Book Volume: 113

Pages Range: 3879-84

Journal Issue: 14

DOI: 10.1073/pnas.1503252113

Abstract

Dysfunctional reward processing is implicated in various mental disorders, including attention deficit hyperactivity disorder (ADHD) and addictions. Such impairments might involve different components of the reward process, including brain activity during reward anticipation. We examined brain nodes engaged by reward anticipation in 1,544 adolescents and identified a network containing a core striatal node and cortical nodes facilitating outcome prediction and response preparation. Distinct nodes and functional connections were preferentially associated with either adolescent hyperactivity or alcohol consumption, thus conveying specificity of reward processing to clinically relevant behavior. We observed associations between the striatal node, hyperactivity, and the vacuolar protein sorting-associated protein 4A (VPS4A) gene in humans, and the causal role of Vps4 for hyperactivity was validated in Drosophila Our data provide a neurobehavioral model explaining the heterogeneity of reward-related behaviors and generate a hypothesis accounting for their enduring nature.

Authors with CRIS profile

Involved external institutions

King’s College London United Kingdom (GB) University of Texas Southwestern Medical Center (UT Southwestern) United States (USA) (US) Fudan University / 复旦大学 China (CN) Ruprecht-Karls-Universität Heidelberg Germany (DE) Trinity College Dublin Ireland (IE) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) French Alternative Energies and Atomic Energy Commission (CEA) France (FR) University of Vermont United States (USA) (US) University of Nottingham United Kingdom (GB) Physikalisch-Technische Bundesanstalt (PTB) Germany (DE) McGill University Canada (CA) University of Paris 11 - Paris-Sud / Université Paris XI Paris-Sud France (FR) University of Toronto Canada (CA) University of California, Berkeley United States (USA) (US) University of Cambridge United Kingdom (GB) Technische Universität Dresden Germany (DE)

How to cite

APA:

Jia, T., Macare, C., Desrivieres, S., Gonzalez, D.A., Tao, C., Ji, X.,... Schumann, G. (2016). Neural basis of reward anticipation and its genetic determinants. Proceedings of the National Academy of Sciences of the United States of America, 113(14), 3879-84. https://dx.doi.org/10.1073/pnas.1503252113

MLA:

Jia, Tianye, et al. "Neural basis of reward anticipation and its genetic determinants." Proceedings of the National Academy of Sciences of the United States of America 113.14 (2016): 3879-84.

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