Putative role of 5-HT2Breceptors in migraine pathophysiology
Segelcke D, Meßlinger K (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 37
Pages Range: 365-371
Journal Issue: 4
Abstract
Objective In this review we attempt to characterize the acute and chronic role of 5-HT2Breceptors with regard to meningeal nociception in animal experiments and clinical data targeting migraine therapy. Background Migraine is a common disabling neurovascular primary headache disease, the pathomechanism of which is still unclear. Serotonin (5-HT) and its receptors might play an important role in some aspects of migraine pathogenesis. The ability of the unselective 5-HT2Breceptor agonist m-chlorophenylpiperazine to induce migraine attacks in migraine sufferers, the high affinity of prophylactic antimigraine drugs to this receptor and its expression in migraine-relevant structures like the dura mater argue for a role of 5-HT2Breceptors in the pathogenesis of migraine attacks. Methods For this review, the relevant databases such as PubMed, MEDLINE®, Cochrane Library and EMBASE, respectively, were searched to December 2015 using the keywords "migraine, 5-HT2, trigeminal, neurogenic inflammation, nitric oxide, nitroxyl, vasodilatation, plasma protein extravasation" and combinations thereof. Conclusion Our literature review suggests an important role of 5-HT2Breceptor activation in meningeal nociception and the generation of migraine pain.
Authors with CRIS profile
Involved external institutions
Germany (DE)How to cite
APA:
Segelcke, D., & Meßlinger, K. (2017). Putative role of 5-HT2Breceptors in migraine pathophysiology. Cephalalgia, 37(4), 365-371. https://doi.org/10.1177/0333102416646760
MLA:
Segelcke, Daniel, and Karl Meßlinger. "Putative role of 5-HT2Breceptors in migraine pathophysiology." Cephalalgia 37.4 (2017): 365-371.
BibTeX: Download