Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging

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Details zur Publikation

Autor(en): Schmidt M, Knott M, Heidemann R, Michelson G, Kober T, Dörfler A, Engelhorn T
Zeitschrift: PLoS ONE
Jahr der Veröffentlichung: 2018
Band: 13
Heftnummer: 6
ISSN: 1932-6203


Abstract

BACKGROUND: There is evidence that glaucoma is a neurodegenerative disease involving the whole visual pathway. We prospectively examined potential benefits of volumetry of the lateral geniculate nucleus (LGN) and diffusion tensor imaging (DTI) using a new 7T scanner.
METHODS: 20 patients with normal tension glaucoma and 16 control individuals were examined. LGN volume and fractional anisotropy (FA) of the optic tract (OT) and the optic radiation (OR) and their correlation with RNFL (retinal nerve fiber layer) thickness were analyzed.
RESULTS: LGN volume was significantly reduced in NTG (60.9 vs 88.3; p < 0.05). FA of the OT (right: 0.35 vs 0.66, left: 0.36 vs 0.67; p < 0.05) and of the OR (right: 0.41 vs 0.70, left: 0.41 vs 0.69; p < 0.05) was also significantly reduced. Nasal RNFL thickness correlated with the volume of the contralateral LGN (r = 0.471, p = 0.05). Temporal RNFL thickness correlated with the volume of the ipsilateral LGN (r = 0.603, p = 0.015).
CONCLUSION: NTG leads to significant atrophy of the LGN compared to controls. FA of the optic tract and the optic radiation is reduced in NTG as sign of axonal degeneration. RNFL thickness but not FA correlates with LGN volume.


FAU-Autoren / FAU-Herausgeber

Dörfler, Arnd Prof. Dr.
Neuroradiologische Abteilung im Radiologischen Institut
Knott, Michael
Medizinische Fakultät
Michelson, Georg Prof. Dr.
Augenklinik
Schmidt, Manuel Dr. med.
Neuroradiologische Abteilung im Radiologischen Institut


Autor(en) der externen Einrichtung(en)
Siemens AG, Healthcare Sector


Zitierweisen

APA:
Schmidt, M., Knott, M., Heidemann, R., Michelson, G., Kober, T., Dörfler, A., & Engelhorn, T. (2018). Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging. PLoS ONE, 13(6). https://dx.doi.org/10.1371/journal.pone.0198830

MLA:
Schmidt, Manuel, et al. "Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging." PLoS ONE 13.6 (2018).

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Zuletzt aktualisiert 2019-05-01 um 14:10