Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging
Schmidt M, Knott M, Heidemann R, Michelson G, Kober T, Dörfler A, Engelhorn T (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 13
Journal Issue: 6
DOI: 10.1371/journal.pone.0198830
Abstract
BACKGROUND: There is evidence that glaucoma is a neurodegenerative disease involving the whole visual pathway. We prospectively examined potential benefits of volumetry of the lateral geniculate nucleus (LGN) and diffusion tensor imaging (DTI) using a new 7T scanner. METHODS: 20 patients with normal tension glaucoma and 16 control individuals were examined. LGN volume and fractional anisotropy (FA) of the optic tract (OT) and the optic radiation (OR) and their correlation with RNFL (retinal nerve fiber layer) thickness were analyzed. RESULTS: LGN volume was significantly reduced in NTG (60.9 vs 88.3; p < 0.05). FA of the OT (right: 0.35 vs 0.66, left: 0.36 vs 0.67; p < 0.05) and of the OR (right: 0.41 vs 0.70, left: 0.41 vs 0.69; p < 0.05) was also significantly reduced. Nasal RNFL thickness correlated with the volume of the contralateral LGN (r = 0.471, p = 0.05). Temporal RNFL thickness correlated with the volume of the ipsilateral LGN (r = 0.603, p = 0.015). CONCLUSION: NTG leads to significant atrophy of the LGN compared to controls. FA of the optic tract and the optic radiation is reduced in NTG as sign of axonal degeneration. RNFL thickness but not FA correlates with LGN volume.
Authors with CRIS profile
Manuel Schmidt
Department of Neuroradiology
Michael Knott
Medizinische Fakultät
Georg Michelson
Department of Ophthalmology
Arnd Dörfler
Department of Neuroradiology
Tobias Martin Engelhorn
Department of Neuroradiology
Additional Organisation(s)
Involved external institutions
Germany (DE)How to cite
APA:
Schmidt, M., Knott, M., Heidemann, R., Michelson, G., Kober, T., Dörfler, A., & Engelhorn, T. (2018). Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging. PLoS ONE, 13(6). https://dx.doi.org/10.1371/journal.pone.0198830
MLA:
Schmidt, Manuel, et al. "Investigation of lateral geniculate nucleus volume and diffusion tensor imaging in patients with normal tension glaucoma using 7 tesla magnetic resonance imaging." PLoS ONE 13.6 (2018).
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