Expert consensus on re-irradiation for recurrent glioma

Krauze A, Attia A, Braunstein S, Chan M, Combs S, Fietkau R, Fiveash J, Flickinger J, Grosu A, Howard S, Nieder C, Niyazi M, Rowe L, Smart DD, Tsien C, Camphausen K (2017)

Publication Type: Journal article

Publication year: 2017

Journal

Radiation Oncology BioMed Central

Book Volume: 12

Journal Issue: 1

DOI: 10.1186/s13014-017-0928-3

Abstract

PURPOSE: To investigate radiation oncologists' opinions on important considerations to offering re-irradiation (re-RT) as a treatment option for recurrent glioma. MATERIALS AND METHODS: A survey was conducted with 13 radiation oncologists involved in the care of central nervous system tumor patients. The survey was comprised of 49 questions divided into 2 domains: a demographic section (10 questions) and a case section (5 re-RT cases with 5 to 6 questions representing one or several re-RT treatment dilemmas as may be encountered in the clinic). Respondents were asked to rate the relevance of various factors to offering re-RT, respond to the cases with a decision to offer re-RT vs. not, volume to be treated, margins to be employed, dose/fractionation suggested and any additional comments with respect to rationale in each scenario. RESULTS: Sixty nine percent of responders have been practicing for greater than 10 years and 61% have re-RT 20 to 100 patients to date, with 54% seeing 2-5 re-RT cases per month and retreating 1-2 patients per month. Recurrent tumor volume, time since previous radiation therapy, previously administered dose to organs at risk and patient performance status were rated by the majority of responders (85%, 92%, 77%, and 69% respectively) as extremely relevant or very relevant to offering re-RT as an option. CONCLUSION: The experts' practice of re-RT is still heterogeneous, reflecting the paucity of high-quality prospective data available for decision-making. Nevertheless, practicing radiation oncologists can support own decisions by referring to the cases found suitable for re-RT in this survey.

Authors with CRIS profile

Rainer Fietkau Lehrstuhl für Strahlentherapie

Involved external institutions

National Cancer Institute (NCI)

United States (USA) (US) Vanderbilt University

United States (USA) (US) University of California San Francisco (UCSF)

United States (USA) (US) Wake Forest University

United States (USA) (US) Technische Universität München (TUM)

Germany (DE) University of Alabama at Birmingham (UAB)

United States (USA) (US) University of Pittsburgh Medical Center (UPMC)

United States (USA) (US) Albert-Ludwigs-Universität Freiburg

Germany (DE) University of Wisconsin - Madison

United States (USA) (US) Universitetet i Tromsø / The Arctic University of Norway (UiT)

Norway (NO) Ludwig-Maximilians-Universität (LMU)

Germany (DE) Washington University

United States (USA) (US)

How to cite

APA:

Krauze, A., Attia, A., Braunstein, S., Chan, M., Combs, S., Fietkau, R.,... Camphausen, K. (2017). Expert consensus on re-irradiation for recurrent glioma. Radiation Oncology, 12(1). https://dx.doi.org/10.1186/s13014-017-0928-3

MLA:

Krauze, Andra, et al. "Expert consensus on re-irradiation for recurrent glioma." Radiation Oncology 12.1 (2017).

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